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    fat3a FAT atypical cadherin 3a [ Danio rerio (zebrafish) ]

    Gene ID: 569256, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fat3aprovided by ZNC
    Official Full Name
    FAT atypical cadherin 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-1254
    See related
    Ensembl:ENSDARG00000033840 AllianceGenome:ZFIN:ZDB-GENE-060929-1254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fat3; zgc:153498
    Summary
    Predicted to enable calcium ion binding activity. Acts upstream of or within cartilage morphogenesis. Predicted to be located in plasma membrane. Is expressed in Meckel's cartilage; palatoquadrate cartilage; and pectoral fin. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See fat3a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (40665394..40993759)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (40708007..41032567)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908864 Neighboring gene uncharacterized LOC137487789 Neighboring gene melatonin receptor type 1Ba Neighboring gene solute carrier family 36 member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. Le Pabic P, et al. PLoS Genet, 2014 Oct. PMID 25340762, Free PMC Article
    2. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Wang X, et al. Biol Open, 2013. PMID 24244857, Free PMC Article
    3. Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Li Y, et al. Gene, 2021 Feb 15. PMID 33164759
    4. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
    5. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153498

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin Fat 3a
    Names
    FAT atypical cadherin 3
    FAT tumor suppressor homolog 3 like
    zmp:0000000581

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077577.3 → NP_001071045.2  protocadherin Fat 3a precursor

      Status: VALIDATED

      Source sequence(s)
      AL929284, CR388051, CR524482
      UniProtKB/TrEMBL
      A0A8M1NBU7, A0A8M9Q0H4, F1QA09
      Related
      ENSDARP00000042081.7, ENSDART00000042082.8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      40665394..40993759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017350986.3 → XP_017206475.1  protocadherin Fat 3a isoform X1

      UniProtKB/TrEMBL
      A0A2R8QAL3, A0A8M6YUT6, A0A8M9Q0H4
      Related
      ENSDARP00000150399.1, ENSDART00000184559.1

    2. XM_021481446.2 → XP_021337121.1  protocadherin Fat 3a isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q0H4, A0A8M9QLG7
      Conserved Domains (4) summary
      cd11304
      Location:3289 → 3385
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:1435 → 1494
      CA; Cadherin repeats
      cd00054
      Location:4147 → 4182
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3914 → 4043
      Laminin_G_2; Laminin G domain

    3. XM_021481445.2 → XP_021337120.1  protocadherin Fat 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0H4, A0A8M9QPX2, X1WCY4
      Related
      ENSDARP00000128081.1, ENSDART00000154187.3
      Conserved Domains (3) summary
      cd11304
      Location:3266 → 3362
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:4124 → 4159
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3891 → 4020
      Laminin_G_2; Laminin G domain

    4. XM_017350989.3 → XP_017206478.1  protocadherin Fat 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z1C0, A0A8M9Q0H4
    Nucleotide Protein
    Heading Accession and Version

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