abcc4 ATP binding cassette subfamily C member 4 (PEL blood group) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcc4provided by ZNC
Official Full Name: ATP binding cassette subfamily C member 4 (PEL blood group)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-511
See related: Ensembl:ENSDARG00000058953 AllianceGenome:ZFIN:ZDB-GENE-030616-511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MRP; lkt; cb1019; sb:eu668; sb:eu872; dZ52I16.4; si:dz52i16.4; si:dz202l16.5; si:busm1-52i16.4
Summary: Enables ABC-type transporter activity; efflux transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Acts upstream of or within detoxification of inorganic compound; prostaglandin secretion; and regulation of cilium assembly. Located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (7322449..7391805)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (7165535..7234620)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.
Title: Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.
zebrafish Abcc4 plays crucial roles in cellular efflux of organochlorine pesticides and can be used a potential molecular marker for the monitor of DDT and lindane contamination in the aquatic environment
Title: Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.
Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde intraflagellar transport, thereby promoting ciliogenesis.
Title: Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Submit: New GeneRIF Correction

General gene information

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Markers

fi88e10.y1 (e-PCR)
- UniSTS:198160

fc10d11.x1 (e-PCR)
- UniSTS:192446

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly ATP-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detoxification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detoxification of inorganic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 4

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; leakytail; multidrug resistance-associated protein member 4

NP_001007039.2

EC 5.6.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007038.2 → NP_001007039.2 ATP-binding cassette sub-family C member 4

Status: VALIDATED

Source sequence(s)

AL953886, BX663606

UniProtKB/TrEMBL

Q8QFL6

Related

ENSDARP00000065499.4, ENSDART00000065500.5

Conserved Domains (1) summary

cl26602
Location:11 → 1289

SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]