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    adam23a ADAM metallopeptidase domain 23a [ Danio rerio (zebrafish) ]

    Gene ID: 794175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adam23aprovided by ZNC
    Official Full Name
    ADAM metallopeptidase domain 23aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070810-2
    See related
    Ensembl:ENSDARG00000062323 AllianceGenome:ZFIN:ZDB-GENE-070810-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    adam23; wu:fj40f01; wu:fq14a08
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in presynaptic membrane. Is expressed in central nervous system. Orthologous to human ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adam23a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (13136562..13187097, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12902286..12953691, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene caspase 8, apoptosis-related cysteine peptidase, like 1 Neighboring gene caspase-8 Neighboring gene caspase 20, apoptosis-related cysteine peptidase Neighboring gene dystrotelin Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene eukaryotic translation elongation factor 1 beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rest represses maturation within migrating facial branchiomotor neurons. Love CE, et al. Dev Biol, 2015 May 15. PMID 25769695, Free PMC Article
    2. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 23
    Names
    ADAM metallopeptidase domain 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      13136562..13187097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001923227.8 → XP_001923262.2  disintegrin and metalloproteinase domain-containing protein 23 isoform X1

      UniProtKB/TrEMBL
      A0A8M1QVD3, F8W3T1
      Related
      ENSDARP00000124043.1, ENSDART00000150036.3
      Conserved Domains (5) summary
      smart00608
      Location:541 → 682
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:254 → 449
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:466 → 538
      Disintegrin; Disintegrin
      pfam01421
      Location:254 → 451
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:97 → 202
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_005165851.5 → XP_005165908.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BD47
      Conserved Domains (5) summary
      smart00608
      Location:541 → 682
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:254 → 449
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:466 → 538
      Disintegrin; Disintegrin
      pfam01421
      Location:254 → 451
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:97 → 202
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_068221911.1 → XP_068078012.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X3

      Related
      ENSDARP00000124198.1, ENSDART00000149940.2
    Nucleotide Protein
    Heading Accession and Version

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