pank2 pantothenate kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pank2provided by ZNC
Official Full Name: pantothenate kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1952
See related: Ensembl:ENSDARG00000003311 AllianceGenome:ZFIN:ZDB-GENE-070112-1952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158667
Summary: Predicted to enable pantothenate kinase activity. Acts upstream of or within nervous system development and vasculature development. Predicted to be active in cytosol and nucleus. Is expressed in axial blood vessel; caudal vein plexus; central nervous system; and epidermis. Used to study pantothenate kinase-associated neurodegeneration. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (15215626..15227857)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (15084634..15096865)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abnormal Vasculature Development in Zebrafish Embryos with Reduced Expression of Pantothenate Kinase 2 Gene.
Title: Abnormal Vasculature Development in Zebrafish Embryos with Reduced Expression of Pantothenate Kinase 2 Gene.
when pank2 or coasy expression was suppressed in zebrafish evident perturbation of neuronal development was observed, as well as severe defects in vasculature formation.
Title: Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis.
Study investigated the expression and function of pank2 during early stages of zebrafish development
Title: Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables pantothenate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantothenate kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in coenzyme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within coenzyme A biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pantothenate kinase 2, mitochondrial

NP_001074075.2

EC 2.7.1.33

XP_005156629.1

EC 2.7.1.33

XP_005156630.1

EC 2.7.1.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080606.2 → NP_001074075.2 pantothenate kinase 2, mitochondrial

Status: VALIDATED

Source sequence(s)

BX323842

UniProtKB/TrEMBL

A0A8M1NCT3, B8A4W8

Related

ENSDARP00000116294.1, ENSDART00000133041.2

Conserved Domains (1) summary

pfam03630
Location:81 → 429

Fumble; Fumble

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

15215626..15227857

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156572.4 → XP_005156629.1 pantothenate kinase 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M2B3B3

Conserved Domains (1) summary

pfam03630
Location:1 → 347

Fumble; Fumble
XM_005156573.4 → XP_005156630.1 pantothenate kinase 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8M2B2L8

Conserved Domains (1) summary

pfam03630
Location:3 → 235

Fumble; Fumble