mybl2a v-myb avian myeloblastosis viral oncogene homolog-like 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mybl2aprovided by ZNC
Official Full Name: v-myb avian myeloblastosis viral oncogene homolog-like 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-529
See related: Ensembl:ENSDARG00000095241 AllianceGenome:ZFIN:ZDB-GENE-980526-529
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd99g04; wu:fd99g04
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal aorta; hematopoietic stem cell; and intermediate cell mass of mesoderm. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (4348265..4357768)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (4409364..4423608)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: v-myb avian myeloblastosis viral oncogene homolog-like 2a

Names: myb; myeloblastosis oncogene; myeloblastosis viral oncogene homolog-like 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309826.1 → NP_001296755.1 v-myb avian myeloblastosis viral oncogene homolog-like 2a

Status: VALIDATED

Source sequence(s)

CU571072, EH555134

UniProtKB/TrEMBL

A0A8M1P1P6, E9QFU4

Related

ENSDARP00000115602.1, ENSDART00000136287.2

Conserved Domains (4) summary

smart00717
Location:79 → 127

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:131 → 176

Myb_DNA-binding; Myb-like DNA-binding domain

pfam05699
Location:714 → 787

Dimer_Tnp_hAT; hAT family C-terminal dimerization region

pfam13921
Location:82 → 139

Myb_DNA-bind_6; Myb-like DNA-binding domain