arhgdia Rho GDP dissociation inhibitor (GDI) alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgdiaprovided by ZNC
Official Full Name: Rho GDP dissociation inhibitor (GDI) alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2816
See related: Ensembl:ENSDARG00000043795 AllianceGenome:ZFIN:ZDB-GENE-040426-2816
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55554; zgc:77681; wu:fa96g11
Summary: Predicted to enable Rho GDP-dissociation inhibitor activity. Acts upstream of or within small GTPase-mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and membrane. Is expressed in retinal ganglion cell layer. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (59899452..59947209)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (59608351..59656108)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fl18f05.x1 (e-PCR)
- UniSTS:202025

fa96g11.x1 (e-PCR)
- UniSTS:202608

AI330615 (e-PCR)
- UniSTS:206826

fb07g08.y1 (e-PCR)
- UniSTS:189949

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.