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    ctn-1 Alpha-catulin [ Caenorhabditis elegans ]

    Gene ID: 171818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctn-1
    Official Full Name
    Alpha-catulin
    Primary source
    WormBase:WBGene00000832
    Locus tag
    CELE_Y23H5A.5
    See related
    AllianceGenome:WB:WBGene00000832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Is expressed in body wall musculature; muscle cell; neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctn-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (2606741..2617360)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Protein pid-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans. Abraham LS, et al. PLoS Genet, 2010 Aug 26. PMID 20865173, Free PMC Article
    2. α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. Chen B, et al. EMBO J, 2010 Sep 15. PMID 20700105, Free PMC Article
    3. Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels. Oh KH, et al. BMC Neurosci, 2015 Apr 24. PMID 25907097, Free PMC Article
    4. Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle. Oh HJ, et al. J Biol Chem, 2012 Jun 22. PMID 22577143, Free PMC Article
    5. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles. Mueller BD, et al. Elife, 2023 Feb 23. PMID 36820519, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation
      Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
    2. An Ctn-1 controls neuromuscular function through localization of the dystrophin complex and SLO-1 channels.
      Title: An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alpha-catulin
    NP_001364770.1
    • Partially confirmed by transcript evidence
    NP_001379944.1
    • Confirmed by transcript evidence
    NP_740814.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2606741..2617360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377804.1 → NP_001364770.1  Alpha-catulin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0F189, H2L011, Q8MPQ6
      Conserved Domains (1) summary
      pfam01044
      Location:114 → 751
      Vinculin; Vinculin family

    2. NM_001393087.1 → NP_001379944.1  Alpha-catulin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0F189, G8JYB2, Q8MPQ6
      Conserved Domains (1) summary
      pfam01044
      Location:100 → 730
      Vinculin; Vinculin family

    3. NM_170830.6 → NP_740814.2  Alpha-catulin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740814.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3U1
      Conserved Domains (1) summary
      pfam01044
      Location:100 → 526
      Vinculin; Vinculin family

    RNA

    1. NR_131363.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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