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    ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 [ Danio rerio (zebrafish) ]

    Gene ID: 393720, updated on 9-Dec-2024

    Summary

    Official Symbol
    ndufv2provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit V2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1713
    See related
    Ensembl:ENSDARG00000013044 AllianceGenome:ZFIN:ZDB-GENE-040426-1713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73198
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; digestive system; optic tectum; optic vesicle; and retina. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ndufv2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (54641775..54690247)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (54911079..54960548)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene microtubule crosslinking factor 1 Neighboring gene acyl-CoA synthetase short chain family member 2 like Neighboring gene ankyrin repeat domain 12 Neighboring gene twisted gastrulation BMP signaling modulator 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC73198

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) flavoprotein 2
    NP_957041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200747.1NP_957041.1  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

      See identical proteins and their annotated locations for NP_957041.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059546
      UniProtKB/TrEMBL
      A0A8M1PEZ8, Q6PBX8
      Related
      ENSDARP00000004700.6, ENSDART00000027313.9
      Conserved Domains (2) summary
      COG1905
      Location:46206
      NuoE; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]
      pfam01257
      Location:58204
      2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      54641775..54690247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)