U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fastkd2 FAST kinase domains 2 [ Danio rerio (zebrafish) ]

    Gene ID: 564382, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fastkd2provided by ZNC
    Official Full Name
    FAST kinase domains 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-7
    See related
    Ensembl:ENSDARG00000074031 AllianceGenome:ZFIN:ZDB-GENE-090313-7
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-103i6.5
    Summary
    Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Used to study combined oxidative phosphorylation deficiency. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 44. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fastkd2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (6221936..6243819)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (5527714..5545996)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, gamma 3a non-catalytic subunit Neighboring gene reticulophagy regulator family member 2 Neighboring gene malate dehydrogenase 1B, NAD (soluble) Neighboring gene general transcription factor IIIC, polypeptide 3 Neighboring gene uncharacterized LOC137495397

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Wei X, et al. Hum Mutat, 2020 May. PMID 31944455
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    FAST kinase domain-containing protein 2; FAST kinase domain-containing protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      6221936..6243819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475935.2 → XP_021331610.1  FAST kinase domain-containing protein 2, mitochondrial

      UniProtKB/TrEMBL
      A0A8N7UR43
      Conserved Domains (2) summary
      smart00952
      Location:577 → 628
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:394 → 463
      FAST_1; FAST kinase-like protein, subdomain 1

    2. XM_687718.10 → XP_692810.5  FAST kinase domain-containing protein 2, mitochondrial

      UniProtKB/TrEMBL
      A0A8N7UR43
      Related
      ENSDARP00000122274.1, ENSDART00000145378.3
      Conserved Domains (2) summary
      smart00952
      Location:577 → 628
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:394 → 463
      FAST_1; FAST kinase-like protein, subdomain 1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools