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    stx3b syntaxin 3b [ Danio rerio (zebrafish) ]

    Gene ID: 393515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stx3bprovided by ZNC
    Official Full Name
    syntaxin 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1489
    See related
    Ensembl:ENSDARG00000001880 AllianceGenome:ZFIN:ZDB-GENE-040426-1489
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    stx3a; zgc:65954
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in exocytosis; intracellular protein transport; and vesicle docking. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in postsynapse; presynaptic active zone membrane; and synaptic vesicle. Is expressed in anterior axial hypoblast; hatching gland; notochord; polster; and retina. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stx3b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21699077..21751335)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21401772..21454101)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908747 Neighboring gene RAN, member RAS oncogene family Neighboring gene lysine (K)-specific demethylase 2Ab Neighboring gene ankyrin repeat domain 13 family, member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina. Curtis L, et al. Neuroscience, 2010 Mar 31. PMID 20060037, Free PMC Article
    2. Photoreceptor coupling is controlled by connexin 35 phosphorylation in zebrafish retina. Li H, et al. J Neurosci, 2009 Dec 2. PMID 19955370, Free PMC Article
    3. Kcnb1 plays a role in development of the inner ear. Jedrychowska J, et al. Dev Biol, 2021 Mar. PMID 33316259
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC65954

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin 3b
    Names
    syntaxin 3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200543.1 → NP_956837.1  syntaxin 3b

      See identical proteins and their annotated locations for NP_956837.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056333
      UniProtKB/TrEMBL
      A0A8M1PCZ8, Q6PHV0
      Related
      ENSDARP00000068197.4, ENSDART00000073707.6
      Conserved Domains (3) summary
      cd00179
      Location:29 → 179
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15881
      Location:188 → 256
      SNARE_syntaxin3; SNARE motif of syntaxin 3
      pfam00804
      Location:29 → 224
      Syntaxin; Syntaxin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21699077..21751335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173108.5 → XP_005173165.1  syntaxin 3b isoform X3

      See identical proteins and their annotated locations for XP_005173165.1

      UniProtKB/TrEMBL
      A0A0R4IXG8, A0A8M9QP33
      Related
      ENSDARP00000140602.1, ENSDART00000169942.2
      Conserved Domains (2) summary
      pfam00804
      Location:29 → 224
      Syntaxin; Syntaxin
      pfam05739
      Location:226 → 276
      SNARE; SNARE domain

    2. XM_005173110.4 → XP_005173167.2  syntaxin 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKE2
      Conserved Domains (1) summary
      pfam00804
      Location:29 → 223
      Syntaxin

    3. XM_005173107.5 → XP_005173164.1  syntaxin 3b isoform X2

      UniProtKB/TrEMBL
      A0A8M2BKT9
      Conserved Domains (3) summary
      cd00179
      Location:29 → 179
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      pfam00804
      Location:29 → 224
      Syntaxin; Syntaxin
      cl22856
      Location:188 → 256
      SNARE; SNARE motif

    4. XM_021480991.2 → XP_021336666.1  syntaxin 3b isoform X4

      UniProtKB/TrEMBL
      A0A8M9QKI8
      Conserved Domains (2) summary
      pfam00804
      Location:29 → 224
      Syntaxin
      cl22856
      Location:192 → 258
      SNARE; SNARE motif

    5. XM_021480992.2 → XP_021336667.1  syntaxin 3b isoform X5

      UniProtKB/TrEMBL
      A0A8M9PZ48, A0A8M9QAZ2
      Conserved Domains (2) summary
      pfam00804
      Location:29 → 224
      Syntaxin
      pfam05739
      Location:225 → 253
      SNARE; SNARE domain

    RNA

    1. XR_011006086.1 RNA Sequence

    2. XR_011006085.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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