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    aplp1 amyloid beta (A4) precursor-like protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 404233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aplp1provided by ZNC
    Official Full Name
    amyloid beta (A4) precursor-like protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040319-1
    See related
    Ensembl:ENSDARG00000098368 AllianceGenome:ZFIN:ZDB-GENE-040319-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aplp; im:7153266; wu:fj55h01
    Summary
    Predicted to enable alpha-2A adrenergic receptor binding activity; alpha-2B adrenergic receptor binding activity; and alpha-2C adrenergic receptor binding activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in nervous system. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aplp1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (37106135..37227453)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (37204410..37328745)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 3, like Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene uncharacterized LOC137487777 Neighboring gene uncharacterized LOC100535321 Neighboring gene uncharacterized LOC100333235 Neighboring gene uncharacterized LOC108179338 Neighboring gene potassium inwardly rectifying channel subfamily J member 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A diaminomaleonitrile-appended BODIPY chemosensor for the selective detection of Cu(2+) via oxidative cyclization and imaging in SiHa cells and zebrafish. Li X, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2020 Jun 5. PMID 32120291
    2. Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Banote RK, et al. Sci Rep, 2020 Jun 23. PMID 32576936, Free PMC Article
    3. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
    4. Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. Karuppan SJ, et al. J Biol Chem, 2022 Feb. PMID 34958801, Free PMC Article
    5. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-2A adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-2B adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-2C adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    amyloid-like protein 1; amyloid beta precursor like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      37106135..37227453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001342885.9 → XP_001342921.4  amyloid beta precursor like protein 1

      UniProtKB/TrEMBL
      A0A0R4IXG2, A0A8M1PZM7
      Related
      ENSDARP00000140309.1, ENSDART00000157762.3
      Conserved Domains (5) summary
      smart00006
      Location:37 → 195
      A4_EXTRA; amyloid A4
      pfam02177
      Location:39 → 139
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:670 → 720
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:141 → 195
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:339 → 520
      APP_E2; E2 domain of amyloid precursor protein
    Nucleotide Protein Strain
    Heading Accession and Version

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