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    ctbp1 C-terminal binding protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 65229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctbp1provided by ZNC
    Official Full Name
    C-terminal binding protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010130-1
    See related
    Ensembl:ENSDARG00000057007 AllianceGenome:ZFIN:ZDB-GENE-010130-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi43a11
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Acts upstream of or within retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ctbp1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (21820034..21846181)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (21522842..21548936)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 2Ab Neighboring gene ankyrin repeat domain 13 family, member D Neighboring gene spondin 2a, extracellular matrix protein Neighboring gene TBC1 domain family, member 10C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio). Muraoka O, et al. Dev Biol, 2000 Dec 1. PMID 11087624
    2. Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons. Sheets L, et al. PLoS One, 2014. PMID 25208216, Free PMC Article
    3. Control of endothelial sprouting by a Tel-CtBP complex. Roukens MG, et al. Nat Cell Biol, 2010 Oct. PMID 20835243
    4. Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. Nadauld LD, et al. J Biol Chem, 2006 Dec 8. PMID 17028196
    5. A two-step model for colon adenoma initiation and progression caused by APC loss. Phelps RA, et al. Cell, 2009 May 15. PMID 19450512, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In zebrafish hair cells exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
      Title: Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
    2. Tel orchestrates endothelial sprouting by binding to the generic co-repressor, CtBP
      Title: Control of endothelial sprouting by a Tel-CtBP complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within retinoic acid receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-terminal-binding protein 1
    NP_571789.3
    XP_005173190.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131714.3 → NP_571789.3  C-terminal-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      BX324205
      UniProtKB/TrEMBL
      Q7ZU55
      Related
      ENSDARP00000107990.1, ENSDART00000122739.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      21820034..21846181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173133.3 → XP_005173190.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKF1, Q7ZU55
      Conserved Domains (2) summary
      COG1052
      Location:100 → 409
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:83 → 401
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394904.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      25031..49762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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