dla deltaA [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlaprovided by ZNC
Official Full Name: deltaAprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-29
See related: Ensembl:ENSDARG00000010791 AllianceGenome:ZFIN:ZDB-GENE-980526-29
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb335; fa04c10; wu:fa04c10
Summary: Predicted to enable Notch binding activity. Acts upstream of or within several processes, including embryonic organ development; nervous system development; and regulation of Notch signaling pathway. Located in cell cortex and plasma membrane. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (54013455..54026180)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (53353712..53366437)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression.
Title: Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression.
an Ngn1-responsive cis-regulatory modules at the zebrafish deltaA locus that functions via the non-redundant interaction of three consensus Ngn E-boxes were identified.
Title: A cluster of non-redundant Ngn1 binding sites is required for regulation of deltaA expression in zebrafish.
DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish.
Title: DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish.
In the adult brain, dla mRNA and Dla protein are expressed in proliferative zones normally associated with stem cells.
Title: DeltaA mRNA and protein distribution in the zebrafish nervous system.
d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism.
Title: d-Asb11 is an essential mediator of canonical Delta-Notch signalling.
Results suggest that Delta/D-Notch 1a signaling is required for spinal cord oligodendrocyte specification.
Title: Delta-Notch signaling regulates oligodendrocyte specification.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

dla (e-PCR), detects polymorphism
- UniSTS:186942

G45863 (e-PCR)
- UniSTS:106665

fa04c10.s1 (e-PCR)
- UniSTS:202194

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within diencephalon development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within diencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within hypochord development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within inner ear receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord cell differentiation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta-like protein A

Names: delta A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130954.2 → NP_571029.2 delta-like protein A precursor

Status: VALIDATED

Source sequence(s)

AL929114

UniProtKB/Swiss-Prot

O57462, Q6DI48

UniProtKB/TrEMBL

A0A8M1PA93, F1R7K3

Related

ENSDARP00000013374.6, ENSDART00000012104.8

Conserved Domains (3) summary

smart00051
Location:161 → 223

DSL; delta serrate ligand

cd00054
Location:331 → 366

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:23 → 94

MNNL; N terminus of Notch ligand