fgfr3 fibroblast growth factor receptor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgfr3provided by ZNC
Official Full Name: fibroblast growth factor receptor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-000816-1
See related: Ensembl:ENSDARG00000004782 AllianceGenome:ZFIN:ZDB-GENE-000816-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc27h01; sb:eu563; wu:fc27h01
Summary: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including fin bud; gut; head; nervous system; and neural rod. Used to study camptodactyly-tall stature-scoliosis-hearing loss syndrome. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (13213566..13294872, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (13081091..13163841, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/beta-catenin signaling.
Title: Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling.
Zebrafish FGFR3 is a negative regulator of interferon (IFN) production in the innate immune response by suppressing the activity of TANK-binding kinase 1 (TBK1) in the process of virus infection.
Title: Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.
Study revealed spatial and temporal distribution of fgfr3 transcript in chondrocytes of the head cartilages, osteoblasts involved in bone formation, ventricular zone of the brain, undifferentiated mesenchymal cells of the skin, and lens epithelium of the eye.
Title: The expression of fgfr3 in the zebrafish head.
Leg1 plays a unique role in protecting liver development under different stress conditions by serving as a secreted signaling molecule/modulator.
Title: Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.

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General gene information

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Markers

fc27h01.x1 (e-PCR)
- UniSTS:193381

fc27h01.x1 (e-PCR)
- UniSTS:187887

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor 3

NP_571681.2

EC 2.7.10.1

XP_009305459.1

EC 2.7.10.1

XP_009305463.1

EC 2.7.10.1

XP_017214284.1

EC 2.7.10.1

XP_021336334.1

EC 2.7.10.1

XP_068069026.1

EC 2.7.10.1

XP_068069027.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131606.2 → NP_571681.2 fibroblast growth factor receptor 3 precursor

Status: VALIDATED

Source sequence(s)

CR556722, CR559942, CU694230, LO018146

UniProtKB/TrEMBL

A0A8M1PBP7, A0A8M9Q9W6, F1QPA0

Related

ENSDARP00000011898.9, ENSDART00000013534.9

Conserved Domains (7) summary

cd04974
Location:280 → 369

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:173 → 257

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:466 → 799

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:67 → 121

IGc2; Immunoglobulin C-2 Type

smart00409
Location:183 → 257

IG; Immunoglobulin

smart00410
Location:272 → 368

IG_like; Immunoglobulin like

pfam07714
Location:479 → 754

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

13213566..13294872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480659.2 → XP_021336334.1 fibroblast growth factor receptor 3 isoform X6

UniProtKB/TrEMBL

A0A8M9Q9X2, A0A8M9QFK2

Conserved Domains (4) summary

cd05857
Location:168 → 252

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:275 → 364

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:462 → 795

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:67 → 121

IGc2; Immunoglobulin C-2 Type
XM_009307188.4 → XP_009305463.1 fibroblast growth factor receptor 3 isoform X5

UniProtKB/TrEMBL

A0A8M3B533, A0A8M9PY42

Conserved Domains (7) summary

cd04974
Location:276 → 365

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:169 → 253

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:463 → 796

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:67 → 121

IGc2; Immunoglobulin C-2 Type

smart00409
Location:179 → 253

IG; Immunoglobulin

smart00410
Location:268 → 364

IG_like; Immunoglobulin like

pfam07714
Location:476 → 751

Pkinase_Tyr; Protein tyrosine kinase
XM_068212925.1 → XP_068069026.1 fibroblast growth factor receptor 3 isoform X3

UniProtKB/TrEMBL

A0A8M9QNI1
XM_068212926.1 → XP_068069027.1 fibroblast growth factor receptor 3 isoform X4

UniProtKB/TrEMBL

A0A8M9QJU0
XM_017358795.3 → XP_017214284.1 fibroblast growth factor receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8M6Z1R4, A0A8M9Q9W6
XM_009307184.4 → XP_009305459.1 fibroblast growth factor receptor 3 isoform X2

UniProtKB/TrEMBL

A0A8M3B7V7, A0A8M9QFJ7

Conserved Domains (7) summary

cd04974
Location:280 → 367

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:173 → 257

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:467 → 800

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:67 → 121

IGc2; Immunoglobulin C-2 Type

smart00409
Location:183 → 257

IG; Immunoglobulin

smart00410
Location:272 → 367

IG_like; Immunoglobulin like

pfam07714
Location:480 → 755

Pkinase_Tyr; Protein tyrosine kinase