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    rdh10b retinol dehydrogenase 10b [ Danio rerio (zebrafish) ]

    Gene ID: 378722, updated on 22-Dec-2024

    Summary

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    Official Symbol
    rdh10bprovided by ZNC
    Official Full Name
    retinol dehydrogenase 10bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030909-7
    See related
    Ensembl:ENSDARG00000012369 AllianceGenome:ZFIN:ZDB-GENE-030909-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb804; rdh10
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in retinol metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including axis; notochord; pleuroperitoneal region; tail bud; and yolk syncytial layer. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rdh10b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30182669..30186307)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30199136..30202774)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily B member 2a Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene ribosomal protein L7 Neighboring gene ubiquitin conjugating enzyme E2 Wa Neighboring gene transfer RNA asparagine (anticodon GUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Nadauld LD, et al. Proc Natl Acad Sci U S A, 2006 Sep 5. PMID 16938888, Free PMC Article
    2. Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. D'Aniello E, et al. PLoS Genet, 2013. PMID 23990796, Free PMC Article
    3. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Lan Y, et al. Cell Rep, 2019 Jan 15. PMID 30650362, Free PMC Article
    4. Shedding new light on early sex determination in zebrafish. King AC, et al. Arch Toxicol, 2020 Dec. PMID 32975586, Free PMC Article
    5. Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration. Blum N, et al. Development, 2012 Jan. PMID 22096078

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 10-B
    Names
    retinol dehydrogenase 10
    NP_958488.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201331.1 → NP_958488.1  retinol dehydrogenase 10-B

      See identical proteins and their annotated locations for NP_958488.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054596
      UniProtKB/Swiss-Prot
      B0V2U0, Q7T2D1
      UniProtKB/TrEMBL
      B2GPJ5
      Related
      ENSDARP00000011528.8, ENSDART00000004903.9
      Conserved Domains (2) summary
      cd05339
      Location:38 → 302
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      COG0300
      Location:36 → 309
      DltE; Short-chain dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30182669..30186307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T2D1.2 GenPept UniProtKB/Swiss-Prot:Q7T2D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.