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    spred1 sprouty related EVH1 domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spred1provided by ZNC
    Official Full Name
    sprouty related EVH1 domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2338
    See related
    Ensembl:ENSDARG00000041449 AllianceGenome:ZFIN:ZDB-GENE-040426-2338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb14c08; fj51c03; zgc:85707; wu:fb14c08; wu:fj51c03
    Summary
    Predicted to enable protein kinase binding activity. Acts upstream of or within blood vessel morphogenesis; lymph vessel development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See spred1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (52639492..52658733, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (52553192..52572433, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene angel homolog 1 (Drosophila) Neighboring gene family with sequence similarity 98 member B Neighboring gene uncharacterized LOC137488151 Neighboring gene trichohyalin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Ablain J, et al. Science, 2018 Nov 30. PMID 30385465, Free PMC Article
    2. SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype. Motta M, et al. Am J Hum Genet, 2021 Nov 4. PMID 34626534, Free PMC Article
    3. miR-126 regulates angiogenic signaling and vascular integrity. Fish JE, et al. Dev Cell, 2008 Aug. PMID 18694566, Free PMC Article
    4. Mir-126 is a conserved modulator of lymphatic development. Kontarakis Z, et al. Dev Biol, 2018 May 15. PMID 29550364
    5. Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Wright K, et al. Life Sci Alliance, 2024 Apr. PMID 38307625, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213232.1 → NP_998397.1  sprouty-related, EVH1 domain-containing protein 1

      See identical proteins and their annotated locations for NP_998397.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068365
      UniProtKB/TrEMBL
      Q6NV01
      Related
      ENSDARP00000060763.5, ENSDART00000060764.6
      Conserved Domains (2) summary
      cd10574
      Location:12 → 123
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:280 → 378
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      52639492..52658733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395000.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      228117..239659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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