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    HAND2 heart and neural crest derivatives expressed 2 [ Gallus gallus (chicken) ]

    Gene ID: 395813, updated on 3-Dec-2024

    Summary

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    Official Symbol
    HAND2provided by CGNC
    Official Full Name
    heart and neural crest derivatives expressed 2provided by CGNC
    Primary source
    CGNC:66214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    dHAND
    Orthologs
    human mouse all
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    Genomic context

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    See HAND2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (42941841..42964036, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (42895356..42917511, complement)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 30 Neighboring gene stimulator of chondrogenesis 1 Neighboring gene uncharacterized LOC101749678 Neighboring gene microRNA 1776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Fernandez-Teran M, et al. Development, 2000 May. PMID 10769237
    2. A subclass of bHLH proteins required for cardiac morphogenesis. Srivastava D, et al. Science, 1995 Dec 22. PMID 8533092
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heart- and neural crest derivatives-expressed protein 2
    Names
    deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204966.3 → NP_990297.2  heart- and neural crest derivatives-expressed protein 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000073
      UniProtKB/TrEMBL
      A0A8V0XEZ9
      Conserved Domains (1) summary
      cd11471
      Location:99 → 160
      bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      42941841..42964036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040698722.2 → XP_040554656.1  heart- and neural crest derivatives-expressed protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEZ9
      Conserved Domains (1) summary
      cd11471
      Location:99 → 160
      bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

    2. XM_040698723.2 → XP_040554657.1  heart- and neural crest derivatives-expressed protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEZ9
      Conserved Domains (1) summary
      cd11471
      Location:99 → 160
      bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      42895356..42917511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046915523.1 → XP_046771479.1  heart- and neural crest derivatives-expressed protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEZ9

    2. XM_046915524.1 → XP_046771480.1  heart- and neural crest derivatives-expressed protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEZ9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90690.1 GenPept UniProtKB/Swiss-Prot:Q90690

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials