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    tmem-24 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-24
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00020012
    Locus tag
    CELE_R11G1.6
    See related
    AllianceGenome:WB:WBGene00020012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in plasma membrane. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2) and C2CD2L (C2CD2 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-24 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (3639166..3644896, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Putative sulfotransferase vep-2 Neighboring gene Glutathione S-Transferase Neighboring gene Serine/threonine-protein kinase sax-1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans. Jeyasimman D, et al. Nat Commun, 2021 Oct 18. PMID 34663803, Free PMC Article
    2. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_001024860.1
    • Confirmed by transcript evidence
    NP_001379604.1
    • Confirmed by transcript evidence
    NP_741752.1
    • Confirmed by transcript evidence
    NP_741753.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3639166..3644896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171654.6 → NP_741752.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPZ6
      Conserved Domains (2) summary
      cd08678
      Location:408 → 532
      C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
      smart00109
      Location:815 → 865
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

    2. NM_171946.7 → NP_741753.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYE1
      Conserved Domains (2) summary
      cd08678
      Location:408 → 532
      C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
      smart00109
      Location:815 → 867
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

    3. NM_001029689.7 → NP_001024860.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z1P8
      Conserved Domains (2) summary
      cd08678
      Location:318 → 442
      C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
      smart00109
      Location:725 → 775
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

    4. NM_001392748.1 → NP_001379604.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z1P9
      Conserved Domains (3) summary
      cd08678
      Location:318 → 442
      C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
      pfam18696
      Location:77 → 222
      SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
      cd20831
      Location:720 → 779
      C1_dGM13116p-like; protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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