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    unc-14 RUN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-14
    Official Full Name
    RUN domain-containing protein
    Primary source
    WormBase:WBGene00006753
    Locus tag
    CELE_K10D3.2
    See related
    AllianceGenome:WB:WBGene00006753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Is expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (7122614..7128246, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glutamate receptor ionotropic, kainate glr-3 Neighboring gene Uncharacterized protein Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Ogura K, et al. Genes Dev, 1997 Jul 15. PMID 9242488
    2. Caenorhabditis elegans HIF-1 Is Broadly Required for Survival in Hydrogen Sulfide. Topalidou I, et al. G3 (Bethesda), 2017 Nov 6. PMID 28889102, Free PMC Article
    3. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Lai T, et al. Development, 2004 Dec. PMID 15539493
    4. The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Ogura K, et al. Development, 2006 Sep. PMID 16887826
    5. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans. Ogura K, et al. Development, 2010 May. PMID 20392746, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The autophagy-related kinase UNC-14 regulates the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
      Title: The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
    2. VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth
      Title: The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
    3. unc-14 binds to kinesin-1 and unc-16 complex and regulates synaptic vesicle localization.
      Title: The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RUN domain-containing protein
    NP_492018.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7122614..7128246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059617.7 → NP_492018.1  RUN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECQ1
      Conserved Domains (1) summary
      smart00593
      Location:471 → 535
      RUN; domain involved in Ras-like GTPase signaling
    Nucleotide Protein
    Heading Accession and Version

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