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    dad-1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 [ Caenorhabditis elegans ]

    Gene ID: 172370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dad-1
    Official Full Name
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
    Primary source
    WormBase:WBGene00000896
    Locus tag
    CELE_F57B10.10
    See related
    AllianceGenome:WB:WBGene00000896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dad-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (6553481..6554290, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inheritance of peroxisomes protein 1 Neighboring gene Cytochrome b-c1 complex subunit 10 Neighboring gene ncRNA Neighboring gene Trehalase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. Sugimoto A, et al. EMBO J, 1995 Sep 15. PMID 7556086, Free PMC Article
    2. Programmed cell death in invertebrates. Hengartner MO. Curr Opin Genet Dev, 1996 Feb. PMID 8791487
    3. Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Hengartner MO. Exp Gerontol, 1997 Jul-Oct. PMID 9315441
    4. Programmed cell death. Conradt B, et al. WormBook, 2005 Oct 6. PMID 18061982, Free PMC Article
    5. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
    NP_491889.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6553481..6554290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059488.7 → NP_491889.1  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52872
      Conserved Domains (1) summary
      pfam02109
      Location:8 → 113
      DAD; DAD family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52872.1

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