Vang Van Gogh [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vangprovided by FlyBase
Official Full Name: Van Goghprovided by FlyBase
Primary source: FLYBASE:FBgn0015838
Locus tag: Dmel_CG8075
See related: AllianceGenome:FB:FBgn0015838
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8075; Dmel\CG8075; stb; Stb; stbm; Stbm; stbm/vang; Strabismus; strabismus/Van Gogh; vang; VANG; vang/stbm; Vang/Stbm; Vangl; vangogh/strabismus
Summary: Enables frizzled binding activity. Involved in several processes, including border follicle cell migration; establishment of planar polarity; and positive regulation of cell projection organization. Located in plasma membrane. Is expressed in dorsal-ventral compartment boundary of the wing disc; organism; wing; and wing disc. Used to study neural tube defect. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1) and VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 45A4-45A6; 2-60 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9103238..9106796)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4990743..4994301)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.
Title: A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.
Report finds that Vang protein is required for the rotation of the DA1/VA1d dendritic pair. Vang functions in the olfactory receptor neurons (ORNs), suggesting a codependence of ORN axonal and projection neuron (PN) dendritic targeting. Loss of Vang suppressed the repulsion of the VA1d dendrites by Wnt5, indicating that Wnt5 signaling through Vang to direct the rotation of the DA1 and VA1d glomeruli.
Title: Interplay between axonal Wnt5-Vang and dendritic Wnt5-Drl/Ryk signaling controls glomerular patterning in the Drosophila antennal lobe.
The authors conclude that Casein Kinase Iepsilon phosphorylation acts as a switch, promoting Strabismus mobility and Dishevelled immobility, thus enhancing sorting of these proteins to opposite cell edges.
Title: Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.
Vang phosphorylation occurs on conserved N-terminal serine/threonine residues, is mediated by CK1epsilon/Dco, and is critical for polarized membrane localization of Vang and other PCP proteins.
Title: Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila.
The transmembrane proteins Frizzled and Flamingo form a stoichiometric nucleus in the complex, while the relative levels of the other four core proteins can vary independently.we show that robust cell polarization is achieved over a range of complex stoichiometries but is dependent on maintaining appropriate levels of the components Frizzled and Strabismus.
Title: Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry.
Data indicate that Kermit interacts with Go and another PCP component Vang during planar cell polarity (PCP).
Title: Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity.
We propose that Stbm recruits farnesylated Pk into asymmetric complexes, but also promotes degradation of excess Pk that would otherwise perturb feedback amplification.
Title: Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification.
It physically interacts with and stabilizes Frizzled, and it mediates intercellular Frizzled-Van Gogh
Title: The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization.
We deduce that each cell has a mechanism to estimate and compare the numbers of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells.
Title: Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
These data suggest that Nemo serves as a conserved molecular link between strabismus and prickle proteins and E-cadherin-beta-catenin complexes, promoting cell motility.
Title: Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of planar polarity	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed