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    H13 histocompatibility 13 [ Mus musculus (house mouse) ]

    Gene ID: 14950, updated on 9-Dec-2024

    Summary

    Official Symbol
    H13provided by MGI
    Official Full Name
    histocompatibility 13provided by MGI
    Primary source
    MGI:MGI:95886
    See related
    Ensembl:ENSMUSG00000019188 AllianceGenome:MGI:95886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spp; H-13; Hm13; PSL3; 1200006O09Rik; 4930443L17Rik; 5031424B04Rik
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Located in cell surface and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; extraembryonic component; and musculoskeletal system. Orthologous to human HM13 (histocompatibility minor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 32.1), ovary adult (RPKM 28.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See H13 in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152511292..152550590)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152669422..152708668)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030C14 gene Neighboring gene STARR-seq mESC enhancer starr_06065 Neighboring gene predicted gene, 31791 Neighboring gene STARR-positive B cell enhancer ABC_E2648 Neighboring gene STARR-seq mESC enhancer starr_06066 Neighboring gene malignant T cell amplified sequence 2 Neighboring gene STARR-seq mESC enhancer starr_06068 Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving  
    enables aspartic endopeptidase activity, intramembrane cleaving  
    enables aspartic endopeptidase activity, intramembrane cleaving  
    enables peptidase activity  
    enables peptidase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex  
    part_of Derlin-1 retrotranslocation complex  
    located_in cell surface PubMed 
    is_active_in cytoplasmic side of endoplasmic reticulum membrane  
    located_in cytoplasmic side of endoplasmic reticulum membrane  
    located_in cytoplasmic side of endoplasmic reticulum membrane  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane PubMed 
    is_active_in lumenal side of endoplasmic reticulum membrane  
    located_in lumenal side of endoplasmic reticulum membrane  
    located_in lumenal side of endoplasmic reticulum membrane  
    located_in plasma membrane  
    located_in rough endoplasmic reticulum  
    located_in rough endoplasmic reticulum  

    General protein information

    Preferred Names
    minor histocompatibility antigen H13
    Names
    presenilin-like aspartyl protease
    presenilin-like protein 3
    signal peptide peptidase beta
    NP_001153023.1
    NP_001153024.1
    NP_001153025.1
    NP_034506.1
    XP_006498846.1
    XP_017171155.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159551.2NP_001153023.1  minor histocompatibility antigen H13 isoform 1

      See identical proteins and their annotated locations for NP_001153023.1

      Status: VALIDATED

      Source sequence(s)
      AL845162
      Consensus CDS
      CCDS50752.1
      UniProtKB/TrEMBL
      A3KGR9
      Related
      ENSMUSP00000086460.3, ENSMUST00000089059.9
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase
    2. NM_001159552.2NP_001153024.1  minor histocompatibility antigen H13 isoform 3

      See identical proteins and their annotated locations for NP_001153024.1

      Status: VALIDATED

      Source sequence(s)
      AL845162
      Consensus CDS
      CCDS50753.1
      UniProtKB/TrEMBL
      Q6PGJ8, Q8HWB1
      Related
      ENSMUSP00000105450.2, ENSMUST00000109825.8
      Conserved Domains (1) summary
      cl01342
      Location:62145
      Peptidase_A22B; Signal peptide peptidase
    3. NM_001159553.2NP_001153025.1  minor histocompatibility antigen H13 isoform 4

      See identical proteins and their annotated locations for NP_001153025.1

      Status: VALIDATED

      Source sequence(s)
      AL845162
      UniProtKB/Swiss-Prot
      Q9D8V0
      Conserved Domains (1) summary
      cl01342
      Location:62123
      Peptidase_A22B; Signal peptide peptidase
    4. NM_010376.5NP_034506.1  minor histocompatibility antigen H13 isoform 2

      See identical proteins and their annotated locations for NP_034506.1

      Status: VALIDATED

      Source sequence(s)
      AL845162
      Consensus CDS
      CCDS16896.1
      UniProtKB/Swiss-Prot
      A3KGS1, O19444, Q15K37, Q3TXP0, Q542R3, Q811Z6, Q8HWA9, Q8HWB5, Q9CQA4, Q9CSK9, Q9D8V0
      UniProtKB/TrEMBL
      A3KGR9
      Related
      ENSMUSP00000120068.2, ENSMUST00000125366.8
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152511292..152550590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498783.5XP_006498846.1  minor histocompatibility antigen H13 isoform X2

      UniProtKB/TrEMBL
      A3KGR9
      Related
      ENSMUSP00000078236.4, ENSMUST00000079247.4
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase
    2. XM_017315666.3XP_017171155.1  minor histocompatibility antigen H13 isoform X1

      Conserved Domains (1) summary
      cl01342
      Location:50157
      Peptidase_A22B; Signal peptide peptidase

    RNA

    1. XR_001780858.3 RNA Sequence

    2. XR_374416.3 RNA Sequence

    3. XR_003950808.2 RNA Sequence

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