Lap3 leucine aminopeptidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lap3provided by MGI
Official Full Name: leucine aminopeptidase 3provided by MGI
Primary source: MGI:MGI:1914238
See related: Ensembl:ENSMUSG00000039682 AllianceGenome:MGI:1914238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lap; Pep7; Peps; LAP-3; Lapep; Pep-7; Pep-S; 2410015L10Rik
Summary: Enables peptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in genital fat pad adult (RPKM 73.0), large intestine adult (RPKM 53.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 24.98 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (45650716..45670033)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (45493374..45512691)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT-TFE3 pathway in C2C12 myoblasts.
Title: The aminopeptidase LAP3 suppression accelerates myogenic differentiation via the AKT-TFE3 pathway in C2C12 myoblasts.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141005 (e-PCR)
- UniSTS:223005

RH124930 (e-PCR)
- UniSTS:161752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cytosol aminopeptidase

Names: cysteinylglycine-S-conjugate dipeptidase; leucyl aminopeptidase; peptidase 7; peptidase S; proline aminopeptidase; prolyl aminopeptidase

NP_077754.3

EC 3.4.11.1

EC 3.4.11.5

EC 3.4.13.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024434.6 → NP_077754.3 cytosol aminopeptidase

See identical proteins and their annotated locations for NP_077754.3

Status: VALIDATED

Source sequence(s)

AC092711, AK011604, BY416332

Consensus CDS

CCDS19274.1

UniProtKB/Swiss-Prot

Q3TFS5, Q4FJV1, Q4FK15, Q99P44, Q9CPY7, Q9CWN8

Related

ENSMUSP00000040222.7, ENSMUST00000046122.11

Conserved Domains (2) summary

PRK00913
Location:36 → 512

PRK00913; multifunctional aminopeptidase A; Provisional

cd00433
Location:33 → 511

Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...