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    Myo16 myosin XVI [ Mus musculus (house mouse) ]

    Gene ID: 244281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo16provided by MGI
    Official Full Name
    myosin XVIprovided by MGI
    Primary source
    MGI:MGI:2685951
    See related
    Ensembl:ENSMUSG00000039057 AllianceGenome:MGI:2685951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NYAP3; Gm1105; mKIAA0865; C230040D10Rik
    Summary
    Predicted to enable actin filament binding activity and protein phosphatase binding activity. Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of myosin complex. Predicted to be active in nucleoplasm and perinuclear region of cytoplasm. Is expressed in central nervous system; metanephros; and white fat. Orthologous to human MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 7.1), CNS E18 (RPKM 3.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myo16 in Genome Data Viewer
    Location:
    8 A1.1; 8 4.77 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10203911..10684742)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10153911..10634742)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 13b Neighboring gene predicted gene 44788 Neighboring gene STARR-seq mESC enhancer starr_20696 Neighboring gene predicted gene, 51560 Neighboring gene STARR-seq mESC enhancer starr_20697 Neighboring gene predicted gene, 51561 Neighboring gene STARR-seq mESC enhancer starr_20698 Neighboring gene predicted gene, 32330 Neighboring gene predicted gene 44785

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Roesler MK, et al. Front Cell Neurosci, 2019. PMID 31474830, Free PMC Article
    2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
    3. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
    4. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Piniella D, et al. Cell Mol Life Sci, 2021 Dec. PMID 34709416, Free PMC Article
    5. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0865

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of myosin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-XVI
    Names
    neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 3
    neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
    unconventional myosin-16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319151.1 → NP_001306080.1  unconventional myosin-XVI

      Status: VALIDATED

      Source sequence(s)
      AK034257, BC072580, BC082311, BC172122
      Consensus CDS
      CCDS40218.2
      UniProtKB/Swiss-Prot
      B2RX94, E1CB68, Q5DU14, Q6GQW7, Q8BUV4
      UniProtKB/TrEMBL
      F8WGF8
      Related
      ENSMUSP00000146677.2, ENSMUST00000207477.2
      Conserved Domains (5) summary
      PHA03095
      Location:70 → 291
      PHA03095; ankyrin-like protein; Provisional
      cd14878
      Location:414 → 1131
      MYSc_Myo16; class XVI myosin, motor domain
      sd00045
      Location:221 → 252
      ANK; ANK repeat [structural motif]
      pfam15439
      Location:1219 → 1583
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:1730 → 1760
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      10203911..10684742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508779.4 → XP_006508842.1  unconventional myosin-XVI isoform X2

      See identical proteins and their annotated locations for XP_006508842.1

      UniProtKB/Swiss-Prot
      B2RX94, E1CB68, Q5DU14, Q6GQW7, Q8BUV4
      UniProtKB/TrEMBL
      F8WGF8
      Conserved Domains (5) summary
      PHA03095
      Location:70 → 291
      PHA03095; ankyrin-like protein; Provisional
      cd14878
      Location:414 → 1131
      MYSc_Myo16; class XVI myosin, motor domain
      sd00045
      Location:221 → 252
      ANK; ANK repeat [structural motif]
      pfam15439
      Location:1219 → 1583
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:1730 → 1760
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    2. XM_006508780.5 → XP_006508843.1  unconventional myosin-XVI isoform X3

      UniProtKB/TrEMBL
      F8WGF8
      Conserved Domains (5) summary
      PHA03095
      Location:92 → 313
      PHA03095; ankyrin-like protein; Provisional
      cd14878
      Location:436 → 1153
      MYSc_Myo16; class XVI myosin, motor domain
      sd00045
      Location:243 → 274
      ANK; ANK repeat [structural motif]
      pfam15439
      Location:1241 → 1605
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:1752 → 1782
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    3. XM_036154016.1 → XP_036009909.1  unconventional myosin-XVI isoform X4

      UniProtKB/TrEMBL
      F8WGF8
      Conserved Domains (4) summary
      PHA03095
      Location:92 → 313
      PHA03095; ankyrin-like protein; Provisional
      cd14878
      Location:436 → 1153
      MYSc_Myo16; class XVI myosin, motor domain
      sd00045
      Location:243 → 274
      ANK; ANK repeat [structural motif]
      pfam15439
      Location:1235 → 1605
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    4. XM_006508778.4 → XP_006508841.1  unconventional myosin-XVI isoform X1

      UniProtKB/TrEMBL
      F8WGF8
      Conserved Domains (5) summary
      PHA03095
      Location:92 → 313
      PHA03095; ankyrin-like protein; Provisional
      cd14878
      Location:436 → 1153
      MYSc_Myo16; class XVI myosin, motor domain
      sd00045
      Location:243 → 274
      ANK; ANK repeat [structural motif]
      pfam15439
      Location:1241 → 1605
      NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
      pfam15452
      Location:1752 → 1782
      NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081397.1: Suppressed sequence

      Description
      NM_001081397.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DU14.2 GenPept UniProtKB/Swiss-Prot:Q5DU14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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