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    Slc28a3 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 114304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc28a3provided by MGI
    Official Full Name
    solute carrier family 28 (sodium-coupled nucleoside transporter), member 3provided by MGI
    Primary source
    MGI:MGI:2137361
    See related
    Ensembl:ENSMUSG00000021553 AllianceGenome:MGI:2137361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnt3
    Summary
    Enables purine-specific nucleoside:sodium symporter activity and pyrimidine- and adenosine-specific:sodium symporter activity. Acts upstream of or within purine nucleoside transmembrane transport and pyrimidine nucleoside transport. Located in brush border membrane. Is expressed in pancreas. Orthologous to human SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 5.2), large intestine adult (RPKM 5.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc28a3 in Genome Data Viewer
    Location:
    13 B1; 13 31.07 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58701121..58758691, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58553307..58610877, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57600 Neighboring gene STARR-positive B cell enhancer ABC_E1464 Neighboring gene predicted gene, 38494 Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene predicted gene, 34058 Neighboring gene RIKEN cDNA 4930455J16 gene Neighboring gene STARR-seq mESC enhancer starr_34692 Neighboring gene ribosomal protein L13, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Ritzel MW, et al. J Biol Chem, 2001 Jan 26. PMID 11032837
    2. Role of the transporter regulator protein (RS1) in the modulation of concentrative nucleoside transporters (CNTs) in epithelia. Errasti-Murugarren E, et al. Mol Pharmacol, 2012 Jul. PMID 22492015
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables purine-specific nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-specific nucleoside:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine- and adenosine-specific:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within purine nucleoside transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleoside transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleoside transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyrimidine-containing compound transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uridine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uridine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 28 member 3
    Names
    CNT 3
    concentrative Na(+)-nucleoside cotransporter 3
    concentrative Na+-nucleoside cotransporter
    mCNT3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022317.3 → NP_071712.3  solute carrier family 28 member 3

      See identical proteins and their annotated locations for NP_071712.3

      Status: VALIDATED

      Source sequence(s)
      AC154222, AF305211, BY736278
      Consensus CDS
      CCDS26572.1
      UniProtKB/Swiss-Prot
      Q3UM72, Q8BWE2, Q91VD7, Q9ERH8
      Related
      ENSMUSP00000022036.8, ENSMUST00000022036.14
      Conserved Domains (4) summary
      TIGR00804
      Location:216 → 627
      nupC; nucleoside transporter
      pfam01773
      Location:221 → 290
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:403 → 627
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:302 → 398
      Gate; Nucleoside recognition

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      58701121..58758691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERH8.1 GenPept UniProtKB/Swiss-Prot:Q9ERH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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