Daxx Fas death domain-associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Daxxprovided by MGI
Official Full Name: Fas death domain-associated proteinprovided by MGI
Primary source: MGI:MGI:1197015
See related: Ensembl:ENSMUSG00000002307 AllianceGenome:MGI:1197015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables histone binding activity and transcription coactivator activity. Involved in several processes, including nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of DNA-templated transcription; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including early embryo; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 30.0), thymus adult (RPKM 18.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34128379..34134564)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33909404..33915590)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAXX safeguards heterochromatin formation in embryonic stem cells.
Title: DAXX safeguards heterochromatin formation in embryonic stem cells.
RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice.
Title: RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice.
Daxx knockdown promoted rDNA transcription without impairing H3.3 expression in mouse preimplantation embryos.
Title: Daxx knockdown promoted rDNA transcription without impairing H3.3 expression in mouse preimplantation embryos.
The histone chaperone function of Daxx is dispensable for embryonic development.
Title: The histone chaperone function of Daxx is dispensable for embryonic development.
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Title: DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Title: Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.
Title: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.
DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase MPK38/MELK.
Title: DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase MPK38/MELK.
Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation.
Title: Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation.
The Effects of Daxx Knockout on Pluripotency and Differentiation of Mouse Induced Pluripotent Stem Cells.
Title: The Effects of Daxx Knockout on Pluripotency and Differentiation of Mouse Induced Pluripotent Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Daxx (e-PCR), detects polymorphism
- UniSTS:463407

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in PML body organization	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to diamide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diamide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: death domain-associated protein 6

Names: death-domain associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199733.1 → NP_001186662.1 death domain-associated protein 6

See identical proteins and their annotated locations for NP_001186662.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK145906, BQ176437, CR974462

Consensus CDS

CCDS28633.1

UniProtKB/TrEMBL

A1A558, Q3UKR0

Related

ENSMUSP00000128504.3, ENSMUST00000170075.9

Conserved Domains (2) summary

cd13150
Location:189 → 393

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 150

Daxx; Daxx N-terminal Rassf1C-interacting domain
NM_001355704.1 → NP_001342633.1 death domain-associated protein 6

Status: VALIDATED

Source sequence(s)

CO041718, CR974462

Consensus CDS

CCDS28633.1

UniProtKB/TrEMBL

A1A558, Q3UKR0

Conserved Domains (2) summary

cd13150
Location:189 → 393

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 150

Daxx; Daxx N-terminal Rassf1C-interacting domain
NM_007829.4 → NP_031855.3 death domain-associated protein 6

See identical proteins and their annotated locations for NP_031855.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK145906, BQ176437, CR974462

Consensus CDS

CCDS28633.1

UniProtKB/TrEMBL

A1A558, Q3UKR0

Related

ENSMUSP00000078390.8, ENSMUST00000079421.15

Conserved Domains (2) summary

cd13150
Location:189 → 393

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 150

Daxx; Daxx N-terminal Rassf1C-interacting domain

RNA

NR_149750.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CO041718, CR974462

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34128379..34134564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523582.4 → XP_006523645.1 death domain-associated protein 6 isoform X1

See identical proteins and their annotated locations for XP_006523645.1

UniProtKB/TrEMBL

A1A558, Q3UKR0

Conserved Domains (2) summary

cd13150
Location:189 → 393

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 150

Daxx; Daxx N-terminal Rassf1C-interacting domain
XM_006523581.4 → XP_006523644.1 death domain-associated protein 6 isoform X1

See identical proteins and their annotated locations for XP_006523644.1

UniProtKB/TrEMBL

A1A558, Q3UKR0

Conserved Domains (2) summary

cd13150
Location:189 → 393

DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

pfam03344
Location:56 → 150

Daxx; Daxx N-terminal Rassf1C-interacting domain