Klf16 Kruppel-like transcription factor 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf16provided by MGI
Official Full Name: Kruppel-like transcription factor 16provided by MGI
Primary source: MGI:MGI:2153049
See related: Ensembl:ENSMUSG00000035397 AllianceGenome:MGI:2153049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DRRF; BTEB4
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within G protein-coupled dopamine receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and retina. Orthologous to human KLF16 (KLF transcription factor 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 29.6), adrenal adult (RPKM 21.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80402955..80413130, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80567121..80577296, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knock out hepatic Kruppel-like factor 16 (KLF16) improve myocardial damage and promoted myocardial protection of myocardial ischemia-reperfusion via anti-oxidative and anti-inflammation effects by TFAM/PPARbeta signal passage.
Title: Knock out hepatic Krüppel-like factor 16 (KLF16) improve myocardial damage and promoted myocardial protection of myocardial ischemia-reperfusion via anti-oxidative and anti-inflammation effects by TFAM/PPARβ signal passage.
results indicate that KLF16 inhibits adipogenesis through downregulation of PPARgamma expression
Title: RNA-Seq Analysis Reveals a Negative Role of KLF16 in Adipogenesis.
methylation of only six of 98 CpG dinucleotides within the EphA5 promoter blocks its transactivation by KLF16 but enables transactivation by KLF2 and KLF15.
Title: Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.
DRRF auto-regulates its own promoter
Title: Transcriptional auto-regulation of the dopamine receptor regulating factor (DRRF) gene.
DRRF mRNA is expressed uniquely during development at all time points tested with high levels observed at E12, E14 and E16 in various tissues
Title: Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492845

AI843742 (e-PCR)
- UniSTS:165707

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 16

Names: BTE-binding protein 4; Kruppel-like factor 16; basic transcription element-binding protein 4; dopamine receptor regulating factor; transcription factor BTEB4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_078477.2 → NP_510962.2 Krueppel-like factor 16

See identical proteins and their annotated locations for NP_510962.2

Status: VALIDATED

Source sequence(s)

AC152058, AK044577

Consensus CDS

CCDS24026.1

UniProtKB/Swiss-Prot

P58334, Q3U3Y4, Q8C8S2

UniProtKB/TrEMBL

B2RPU7

Related

ENSMUSP00000048825.9, ENSMUST00000038558.9

Conserved Domains (3) summary

COG5048
Location:124 → 186

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:128 → 150

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:172 → 197

zf-H2C2_2; Zinc-finger double domain