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    Calu calumenin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64366, updated on 9-Dec-2024

    Summary

    Official Symbol
    Caluprovided by RGD
    Official Full Name
    calumeninprovided by RGD
    Primary source
    RGD:620383
    See related
    EnsemblRapid:ENSRNOG00000006197 AllianceGenome:RGD:620383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rcn; Cbp50
    Summary
    Enables calcium ion binding activity; enzyme binding activity; and enzyme inhibitor activity. Involved in peripheral nervous system axon regeneration and response to organic cyclic compound. Located in endoplasmic reticulum lumen. Orthologous to human CALU (calumenin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 931.3), Lung (RPKM 569.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Calu in Genome Data Viewer
    Location:
    4q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58914456..58941957)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57949086..57976589)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56625611..56653112)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692085 Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene golgi associated RAB2 interactor 1B Neighboring gene opsin 1, short wave sensitive Neighboring gene transfer RNA proline (anticodon AGG) 6

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124555

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peripheral nervous system axon regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calumenin
    Names
    CBP-50
    crocalbin
    reticulocalbin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033898.1NP_001029070.1  calumenin isoform b precursor

      See identical proteins and their annotated locations for NP_001029070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one alternate in-frame exon and contains another alternate in-frame exon compare to variant 1. The resulting isoform (b) is of the same size as isoform a, but it differs in its internal aa sequence.
      Source sequence(s)
      BC101908
      UniProtKB/TrEMBL
      A0A0G2K4X7, A6IEC6, F7ETZ4, Q3MID6
      Related
      ENSRNOP00000008972.6, ENSRNOT00000008972.8
      Conserved Domains (3) summary
      cd00051
      Location:157214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:157214
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:193258
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_022535.2NP_071980.2  calumenin isoform a precursor

      See identical proteins and their annotated locations for NP_071980.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Both isoforms are of the same length but differ in their internal aa sequence.
      Source sequence(s)
      BC101908, CK476875
      UniProtKB/TrEMBL
      A6IEC5, G3V6S3
      Related
      ENSRNOP00000008356.5, ENSRNOT00000008356.7
      Conserved Domains (3) summary
      cd00051
      Location:157214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:157214
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:193258
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      58914456..58941957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)