Ppp1r3b protein phosphatase 1, regulatory subunit 3B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r3bprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 3Bprovided by RGD
Primary source: RGD:621600
See related: EnsemblRapid:ENSRNOG00000011474 AllianceGenome:RGD:621600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables [phosphorylase] phosphatase activity; enzyme binding activity; and protein phosphatase regulator activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 440.7), Thymus (RPKM 128.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (63533318..63545683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (56830011..56842395, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (60415192..60427498, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Title: Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143497 (e-PCR)
- UniSTS:232744

AU048745 (e-PCR)
- UniSTS:145195

BE113230 (e-PCR)
- UniSTS:246640

PMC154451P1 (e-PCR)
- UniSTS:271311

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables [phosphorylase] phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glycogen catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in glycogen granule	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 3B

Names: 33 kDa glycogen-binding protein; PP1 subunit R4; R4; hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; protein phosphatase 1 (GL-subunit); protein phosphatase 1 regulatory subunit 4; protein phosphatase 1 subunit GL; protein phosphatase 1, regulatory (inhibitor) subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434432.1 → NP_001421361.1 protein phosphatase 1 regulatory subunit 3B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q63759, Q6IN01

UniProtKB/TrEMBL

A6IVM9
NM_001434433.1 → NP_001421362.1 protein phosphatase 1 regulatory subunit 3B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q63759, Q6IN01

UniProtKB/TrEMBL

A6IVM9
NM_138912.3 → NP_620267.2 protein phosphatase 1 regulatory subunit 3B

See identical proteins and their annotated locations for NP_620267.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q63759, Q6IN01

UniProtKB/TrEMBL

A6IVM9

Related

ENSRNOP00000108106.1, ENSRNOT00000148975.1

Conserved Domains (1) summary

pfam03370
Location:126 → 231

CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

63533318..63545683 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253216.5 → XP_006253278.1 protein phosphatase 1 regulatory subunit 3B isoform X1

Conserved Domains (1) summary

pfam03370
Location:126 → 231

CBM_21; Carbohydrate/starch-binding module (family 21)
XM_006253215.4 → XP_006253277.1 protein phosphatase 1 regulatory subunit 3B isoform X1

Related

ENSRNOP00000042713.2, ENSRNOT00000051720.4

Conserved Domains (1) summary

pfam03370
Location:126 → 231

CBM_21; Carbohydrate/starch-binding module (family 21)