U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297554, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Csgalnact2provided by RGD
    Official Full Name
    chondroitin sulfate N-acetylgalactosaminyltransferase 2provided by RGD
    Primary source
    RGD:1563660
    See related
    EnsemblRapid:ENSRNOG00000014713 AllianceGenome:RGD:1563660
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Galnact2; RGD1563660
    Summary
    Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process and dermatan sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 242.4), Muscle (RPKM 183.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Csgalnact2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (152944154..152981237, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151271774..151308856, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (150148626..150185062, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102376 Neighboring gene uncharacterized LOC134486839 Neighboring gene RasGEF domain family, member 1A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene developmental pluripotency-associated 3, pseudogene 3 Neighboring gene ret proto-oncogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. Uyama T, et al. J Biol Chem, 2002 Mar 15. PMID 11788602
    2. Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Izumikawa T, et al. Biochem J, 2011 Mar 1. PMID 21138417
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dermatan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    chondroitin sulfate N-acetylgalactosaminyltransferase 2
    Names
    chondroitin sulfate GalNAcT-2
    NP_001100086.1
    XP_006237243.1
    XP_006237244.1
    XP_017448072.1
    XP_017448073.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106616.1 → NP_001100086.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2

      See identical proteins and their annotated locations for NP_001100086.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IL55, D4A5Z0
      Related
      ENSRNOP00000019778.4, ENSRNOT00000019778.6
      Conserved Domains (1) summary
      cl11394
      Location:67 → 516
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      152944154..152981237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592584.3 → XP_017448073.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2

    2. XM_006237181.4 → XP_006237243.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X3

      Conserved Domains (1) summary
      cl11394
      Location:166 → 436
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    3. XM_017592583.3 → XP_017448072.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A6IL55, D4A5Z0
      Conserved Domains (1) summary
      cl11394
      Location:67 → 516
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    4. XM_006237182.5 → XP_006237244.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X4

      Conserved Domains (1) summary
      cl11394
      Location:67 → 445
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous