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    Psmg1 proteasome assembly chaperone 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmg1provided by RGD
    Official Full Name
    proteasome assembly chaperone 1provided by RGD
    Primary source
    RGD:1305454
    See related
    EnsemblRapid:ENSRNOG00000001643 AllianceGenome:RGD:1305454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dscr2
    Summary
    Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and proteasome core complex assembly. Predicted to act upstream of or within cerebellar granule cell precursor proliferation. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in endoplasmic reticulum. Orthologous to human PSMG1 (proteasome assembly chaperone 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 98.1), Kidney (RPKM 80.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmg1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48745581..48755040, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (35276080..35285541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (36327798..36337289, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693523 Neighboring gene uncharacterized LOC108352314 Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene microRNA 6324 Neighboring gene large ribosomal subunit protein eL43-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and cellular characterization of the Down syndrome critical region protein 2. Vesa J, et al. Biochem Biophys Res Commun, 2005 Mar 4. PMID 15670775
    2. DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells. Possik PA, et al. Eur J Histochem, 2004 Jul-Sep. PMID 15590417
    3. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
    4. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
    5. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Hirano Y, et al. Nature, 2005 Oct 27. PMID 16251969

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellar granule cell precursor proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome core complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasome core complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteasome assembly chaperone 1
    Names
    Down syndrome critical region gene 2
    Down syndrome critical region homolog 2
    proteasome (prosome, macropain) assembly chaperone 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399237.1 → NP_001386166.1  proteasome assembly chaperone 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6KPT1, D4AAH6
      Related
      ENSRNOP00000100896.1, ENSRNOT00000121972.1
      Conserved Domains (1) summary
      pfam16094
      Location:2 → 288
      PAC1; Proteasome assembly chaperone 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48745581..48755040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105891.1: Suppressed sequence

      Description
      NM_001105891.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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