Scamp1 secretory carrier membrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scamp1provided by RGD
Official Full Name: secretory carrier membrane protein 1provided by RGD
Primary source: RGD:3625
See related: EnsemblRapid:ENSRNOG00000061582 AllianceGenome:RGD:3625
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein domain specific binding activity. Involved in endocytosis. Located in clathrin-coated vesicle. Is active in synaptic vesicle membrane. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 263.0), Adrenal (RPKM 224.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (27168863..27251637, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (25433958..25516734, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (23858021..23941128, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that SCAMP1's apparent dual role in facilitating dilation and closure of fusion pores implicates its function in exo-endocytic coupling and in the regulation of partial secretion.
Title: Regulation of fusion pore closure and compound exocytosis in neuroendocrine PC12 cells by SCAMP1.
SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
SCAMPs travel between the cell surface and internal recycling systems, and form a mosaic with individual isoforms marking distinct pathways and functioning as trafficking machinery at sites of vesicle formation and fusion.
Title: Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133854 (e-PCR)
- UniSTS:217137

RH136851 (e-PCR)
- UniSTS:218940

Mbd3 (e-PCR), detects polymorphism
- UniSTS:498797

RH132413 (e-PCR)
- UniSTS:215696

RH126839 (e-PCR)
- UniSTS:208574

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretory carrier-associated membrane protein 1

Names: SCAMP 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100636.1 → NP_001094106.1 secretory carrier-associated membrane protein 1

See identical proteins and their annotated locations for NP_001094106.1

Status: VALIDATED

Source sequence(s)

BC090322, CB740599, L22079

UniProtKB/Swiss-Prot

P56603

UniProtKB/TrEMBL

A0A0G2JY82

Related

ENSRNOP00000070553.2, ENSRNOT00000084044.3

Conserved Domains (1) summary

pfam04144
Location:117 → 292

SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

27168863..27251637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102030.2 → XP_038957958.1 secretory carrier-associated membrane protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K1I6, A0A8I6ARE5, A6I4W5

Related

ENSRNOP00000071856.2, ENSRNOT00000084729.3

Conserved Domains (1) summary

pfam04144
Location:117 → 258

SCAMP; SCAMP family
XM_039102028.2 → XP_038957956.1 secretory carrier-associated membrane protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A1V6, Q5D009

Related

ENSRNOP00000096839.2, ENSRNOT00000115933.2

Conserved Domains (1) summary

pfam04144
Location:91 → 266

SCAMP; SCAMP family
XM_039102031.2 → XP_038957959.1 secretory carrier-associated membrane protein 1 isoform X3

UniProtKB/TrEMBL

Q5D009

Related

ENSRNOP00000086247.2, ENSRNOT00000093847.2

Conserved Domains (2) summary

pfam04144
Location:65 → 240

SCAMP; SCAMP family

cl03075
Location:13 → 63

GrpE; nucleotide exchange factor GrpE