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    Gtf2h5 general transcription factor IIH subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2h5provided by RGD
    Official Full Name
    general transcription factor IIH subunit 5provided by RGD
    Primary source
    RGD:1560991
    See related
    EnsemblRapid:ENSRNOG00000018007 AllianceGenome:RGD:1560991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560991
    Summary
    Predicted to be involved in nucleotide-excision repair, preincision complex assembly and transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to gamma radiation; nucleotide-excision repair; and rRNA metabolic process. Predicted to be located in nucleolus. Predicted to be part of transcription factor TFIID complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 103.0), Kidney (RPKM 90.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2h5 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49061904..49068612)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46656804..46663512)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (46978345..46985032)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptojanin 2 Neighboring gene uncharacterized LOC134482650 Neighboring gene uncharacterized LOC120099116 Neighboring gene serine active site containing 1 Neighboring gene uncharacterized LOC102551377 Neighboring gene TUB like protein 4 Neighboring gene transfer RNA proline (anticodon AGG) 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. Theil AF, et al. PLoS Genet, 2013 Apr. PMID 23637614, Free PMC Article
    2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
    3. Nucleotide excision repair: new tricks with old bricks. Kamileri I, et al. Trends Genet, 2012 Nov. PMID 22824526
    4. Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing. Nonnekens J, et al. Hum Mol Genet, 2013 Jul 15. PMID 23562818
    5. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair, preincision complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair, preincision complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription elongation by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 5
    Names
    general transcription factor IIH, polypeptide 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126088.1 → NP_001119560.1  general transcription factor IIH subunit 5

      See identical proteins and their annotated locations for NP_001119560.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474077
      UniProtKB/TrEMBL
      A6KP01, D3ZEI7
      Conserved Domains (1) summary
      pfam06331
      Location:1 → 69
      Tfb5; Transcription factor TFIIH complex subunit Tfb5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49061904..49068612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227894.4 → XP_006227956.1  general transcription factor IIH subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_006227956.1

      UniProtKB/TrEMBL
      A6KP01, D3ZEI7
      Related
      ENSRNOP00000024211.5, ENSRNOT00000024211.7
      Conserved Domains (1) summary
      pfam06331
      Location:1 → 69
      Tfb5; Transcription factor TFIIH complex subunit Tfb5
    Nucleotide Protein Strain
    Heading Accession and Version

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