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    C4H cinnamate-4-hydroxylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817599, updated on 18-Sep-2024

    Summary

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    Official Symbol
    C4H
    Official Full Name
    cinnamate-4-hydroxylase
    Primary source
    TAIR:AT2G30490
    Locus tag
    AT2G30490
    See related
    Araport:AT2G30490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATC4H; CINNAMATE 4-HYDROXYLASE; cinnamate-4-hydroxylase; CINNAMATE-4-HYDROXYLASE; CYP73A5; REDUCED EPRDERMAL FLUORESCENCE 3; REF3; T6B20.16; T6B20_16
    Summary
    Encodes a cinnamate-4-hydroxylase. Mutations in this gene impact phenylpropanoid metabolism, growth and development.
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    Genomic context

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    See C4H in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (12993625..12996012, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene B3 domain-containing transcription repressor VAL1 Neighboring gene uncharacterized protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Phototropic-responsive NPH3 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant. Kim JI, et al. J Exp Bot, 2021 Apr 2. PMID 33585900
    2. Cinnamate-4-hydroxylase expression in Arabidopsis. Regulation in response to development and the environment. Bell-Lelong DA, et al. Plant Physiol, 1997 Mar. PMID 9085570, Free PMC Article
    3. Isolation of a cDNA and a genomic clone encoding cinnamate 4-hydroxylase from Arabidopsis and its expression manner in planta. Mizutani M, et al. Plant Physiol, 1997 Mar. PMID 9085571, Free PMC Article
    4. Mutations in the cinnamate 4-hydroxylase gene impact metabolism, growth and development in Arabidopsis. Schilmiller AL, et al. Plant J, 2009 Dec. PMID 19682296
    5. Chemical Genetics Uncovers Novel Inhibitors of Lignification, Including p-Iodobenzoic Acid Targeting CINNAMATE-4-HYDROXYLASE. Van de Wouwer D, et al. Plant Physiol, 2016 Sep. PMID 27485881, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant.
      Title: Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant.
    2. Data indicate that p-iodobenzoic acid was characterized as a new inhibitor of CINNAMATE 4-HYDROXYLASE, a key enzyme of the phenylpropanoid pathway synthesizing the building blocks of the lignin polymer.
      Title: Chemical Genetics Uncovers Novel Inhibitors of Lignification, Including p-Iodobenzoic Acid Targeting CINNAMATE-4-HYDROXYLASE.
    3. CYP73A5 and CYP98A3, the two Arabidopsis cytochrome P450s (P450s) catalyzing para- and meta-hydroxylations of the phenolic ring of monolignols were found to colocalize in the endoplasmic reticulum (ER) and to form homo- and heteromers.
      Title: Protein-protein and protein-membrane associations in the lignin pathway.
    4. C4H function is critical to normal development of Arabidopsis.
      Title: Mutations in the cinnamate 4-hydroxylase gene impact metabolism, growth and development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128601.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables trans-cinnamate 4-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    cinnamate-4-hydroxylase
    NP_180607.1
    • cinnamate-4-hydroxylase (C4H); FUNCTIONS IN: trans-cinnamate 4-monooxygenase activity; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, membrane, plant-type cell wall; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 3 (TAIR:AT2G40890.1); Has 31278 Blast hits to 31002 proteins in 1609 species: Archae - 48; Bacteria - 2734; Metazoa - 11804; Fungi - 6596; Plants - 9113; Viruses - 3; Other Eukaryotes - 980 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12993625..12996012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128601.3 → NP_180607.1  cinnamate-4-hydroxylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180607.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04995, O49834, P92993, P92994
      UniProtKB/TrEMBL
      A0A178VRU1, B1GV39, B1GV49
      Conserved Domains (1) summary
      PLN02394
      Location:3 → 505
      PLN02394; trans-cinnamate 4-monooxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92994.1

    Gene LinkOut

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