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    BRIZ2 zinc finger (C3HC4-type RING finger) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817141, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BRIZ2
    Official Full Name
    zinc finger (C3HC4-type RING finger) family protein
    Primary source
    TAIR:AT2G26000
    Locus tag
    AT2G26000
    See related
    Araport:AT2G26000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BRAP2 RING ZnF UBP domain-containing protein 2; T19L18.19; T19L18_19
    Summary
    Encodes a RING domain containing protein BRIZ2. BRIZ1 (At2g42160) and BRIZ2 (At2g26000) proteins form a heteromeric E3 ligase complex required for seed germination and post-germination growth.
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    Genomic context

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    See BRIZ2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (11081156..11085382)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Mannose-binding lectin superfamily protein Neighboring gene uncharacterized protein Neighboring gene plant defensin 1.3 Neighboring gene plant defensin 1.2b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BRIZ1 and BRIZ2 proteins form a heteromeric E3 ligase complex required for seed germination and post-germination growth in Arabidopsis thaliana. Hsia MM, et al. J Biol Chem, 2010 Nov 19. PMID 20810661, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036342.3
    NM_001336033.1
    NM_128159.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    part_of ubiquitin ligase complex IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger (C3HC4-type RING finger) family protein
    NP_001031419.1
    • BRAP2 RING ZnF UBP domain-containing protein 2 (BRIZ2); FUNCTIONS IN: catalytic activity, zinc ion binding; LOCATED IN: chloroplast; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: BRCA1-associated 2 (InterPro:IPR011422), Zinc finger, UBP-type (InterPro:IPR001607), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: zinc finger (ubiquitin-hydrolase) domain-containing protein (TAIR:AT2G42160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_180170.2
    • BRAP2 RING ZnF UBP domain-containing protein 2 (BRIZ2); FUNCTIONS IN: catalytic activity, zinc ion binding; LOCATED IN: chloroplast; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: BRCA1-associated 2 (InterPro:IPR011422), Zinc finger, UBP-type (InterPro:IPR001607), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: zinc finger (ubiquitin-hydrolase) domain-containing protein (TAIR:AT2G42160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11081156..11085382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036342.3 → NP_001031419.1  zinc finger (C3HC4-type RING finger) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178W1J8, O80996
      UniProtKB/TrEMBL
      A0A384KPU1, A0A5S9X1H5, A0A7G2EDB4
      Conserved Domains (4) summary
      cd16457
      Location:165 → 208
      RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
      pfam02148
      Location:218 → 280
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam07576
      Location:57 → 148
      BRAP2; BRCA1-associated protein 2
      NF033777
      Location:331 → 446
      M_group_A_cterm; M protein C-terminal domain

    2. NM_128159.2 → NP_180170.2  zinc finger (C3HC4-type RING finger) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180170.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EDB4, F4ITK6
      Conserved Domains (4) summary
      cd00162
      Location:166 → 207
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02148
      Location:218 → 280
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam07576
      Location:57 → 148
      BRAP2; BRCA1-associated protein 2
      pfam13863
      Location:315 → 419
      DUF4200; Domain of unknown function (DUF4200)

    3. NM_001336033.1 → NP_001323647.1  zinc finger (C3HC4-type RING finger) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178W1J8, O80996
      UniProtKB/TrEMBL
      A0A384KPU1, A0A5S9X1H5, A0A7G2EDB4
      Conserved Domains (4) summary
      cd16457
      Location:165 → 208
      RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
      pfam02148
      Location:218 → 280
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam07576
      Location:57 → 148
      BRAP2; BRCA1-associated protein 2
      NF033777
      Location:331 → 446
      M_group_A_cterm; M protein C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80996.1

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