GGT1 glutamate:glyoxylate aminotransferase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GGT1
Official Full Name: glutamate:glyoxylate aminotransferase
Primary source: TAIR:AT1G23310
Locus tag: AT1G23310
See related: Araport:AT1G23310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ALANINE-2-OXOGLUTARATE AMINOTRANSFERASE 1; AOAT1; F26F24.16; F26F24_16; GGAT1; glutamate:glyoxylate aminotransferase; GLUTAMATE:GLYOXYLATE AMINOTRANSFERASE; GLUTAMATE:GLYOXYLATE AMINOTRANSFERASE 1
Summary: Identified by cloning the gene that corresponded to a purified protein having glyoxylate aminotransferase activity. Localized to the peroxisome and thought to be involved in photorespiration/ metabolic salvage pathway.
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Genomic context

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See GGT1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (8268385..8272021, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that apoplastic GGT silencing induces a decrease in the number of organs with a high GSH demand (seeds and trichomes) as a result of resource reallocation to preserve integrity and composition.
Title: Apoplastic gamma-glutamyl transferase activity encoded by GGT1 and GGT2 is important for vegetative and generative development.
Data indicate that intron-mediated enhancement (IME) of the GGT1 5'UTR intron is controlled on the transcriptional level, and that the abundance of RNA polymerase II binding to the intron-less construct is reduced.
Title: The 5'UTR Intron of Arabidopsis GGT1 Aminotransferase Enhances Promoter Activity by Recruiting RNA Polymerase II.
GGT1 protein plays a role in maintaining leaf carbon/nitrogen balance by reducing RuBisCO content and plant growth.
Title: Arabidopsis thaliana ggt1 photorespiratory mutants maintain leaf carbon/nitrogen balance by reducing RuBisCO content and plant growth.
These observations suggest that GGT1 is important in preventing oxidative stress by metabolizing extracellular glutathione disulfide, while GGT2 might be important in transporting glutathione into developing seeds.
Title: Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis.
Mutations in GGT1 result in altered abscisic acid sensitivity.
Title: Altered ABA, proline and hydrogen peroxide in an Arabidopsis glutamate:glyoxylate aminotransferase mutant.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036006.1

Supported by ESTs:

NM_102180.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-alanine:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alanine-glyoxylate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photorespiration	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within photorespiration	TAS Traceable Author Statement more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in peroxisome	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: glutamate:glyoxylate aminotransferase

NP_001031083.1

glutamate:glyoxylate aminotransferase (GGT1); FUNCTIONS IN: glycine:2-oxoglutarate aminotransferase activity, L-alanine:2-oxoglutarate aminotransferase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome, vacuole, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: alanine-2-oxoglutarate aminotransferase 2 (TAIR:AT1G70580.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_564192.2

glutamate:glyoxylate aminotransferase (GGT1); FUNCTIONS IN: glycine:2-oxoglutarate aminotransferase activity, L-alanine:2-oxoglutarate aminotransferase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: apoplast, peroxisome, chloroplast, vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: alanine-2-oxoglutarate aminotransferase 2 (TAIR:AT1G70580.4); Has 27976 Blast hits to 27968 proteins in 2949 species: Archae - 777; Bacteria - 19095; Metazoa - 617; Fungi - 736; Plants - 1276; Viruses - 0; Other Eukaryotes - 5475 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

8268385..8272021 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102180.4 → NP_564192.2 glutamate:glyoxylate aminotransferase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564192.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFR2, Q93Z05, Q94B22, Q9C5K2, Q9LR30

UniProtKB/TrEMBL

A0A178WG36, A0A5S9VPG3, A0A5S9WRJ0, A0A654EPB3

Conserved Domains (1) summary

PLN02368
Location:1 → 406

PLN02368; alanine transaminase
NM_001036006.1 → NP_001031083.1 glutamate:glyoxylate aminotransferase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031083.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9WRJ0, A0A654EPB3

Conserved Domains (2) summary

cd00609
Location:80 → 435

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PLN02368
Location:1 → 406

PLN02368; alanine transaminase