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    RECQ4A DNA helicase (RECQl4A) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837636, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RECQ4A
    Official Full Name
    DNA helicase (RECQl4A)
    Primary source
    TAIR:AT1G10930
    Locus tag
    AT1G10930
    See related
    Araport:AT1G10930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRECQ4A; ATSGS1; T19D16.15; T19D16_15
    Summary
    DNA helicase involved in the maintenance of genome stability by modulation of the DNA damage response and suppression of homologous recombination.
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    Genomic context

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    See RECQ4A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Sequence:
    Chromosome: 1; NC_003070.9 (3647876..3655685, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-4-phosphate 5-kinase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene Protein kinase superfamily protein Neighboring gene transmembrane nine 1 Neighboring gene ferredoxin 1 Neighboring gene zinc transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis. Schröpfer S, et al. Nucleic Acids Res, 2014 Feb. PMID 24174542, Free PMC Article
    2. The RecQ helicase AtRECQ4A is required to remove inter-chromosomal telomeric connections that arise during meiotic recombination in Arabidopsis. Higgins JD, et al. Plant J, 2011 Feb. PMID 21265901
    3. Arabidopsis RecQI4A suppresses homologous recombination and modulates DNA damage responses. Bagherieh-Najjar MB, et al. Plant J, 2005 Sep. PMID 16146519
    4. Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Hartung F, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18000056, Free PMC Article
    5. Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis. Zhu L, et al. Proc Natl Acad Sci U S A, 2021 Aug 17. PMID 34385313, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
      Title: Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
    2. Data show that DNA polymerase zeta catalytic subunit REV3 cooperates with ATP-dependent DNA helicase RECQ4A and e ndonuclease MUS81 to repair DNA interstrand cross links.
      Title: The Translesion Polymerase ζ Has Roles Dependent on and Independent of the Nuclease MUS81 and the Helicase RECQ4A in DNA Damage Repair in Arabidopsis.
    3. Data indicate that both topoisomerase3alpha (TOP3alpha) and RECQ4A/B helicases act independently of the anti-meiotic crossovers (COs) Fanconi anemia of complementation group M (FANCM) helicase.
      Title: Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.
    4. The N-terminus of RECQ4A was determined to be required for its specific functions in DNA repair and recombination.
      Title: Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
    5. Pollen viability decreased in Atrecq4A, resulting in a reduction in fertility.Immunolocalization confirmed the association of AtRECQ4A with the telomeres during prophase I.
      Title: The RecQ helicase AtRECQ4A is required to remove inter-chromosomal telomeric connections that arise during meiotic recombination in Arabidopsis.
    6. RECQ4A and MUS81 define RAD5A-independent pathways of DNA repair. RAD5A and RECQ4A act through two independent pathways for intrastrand cross-link DNA repair. RECQ4A and MUS81 act in parallel pathways to resolve replication-associated DNA intermediates.
      Title: RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.
    7. Roles for Arabidopsis RecQl4A in maintenance of genome stability by modulation of the DNA damage response and suppression of HR are reported.
      Title: Arabidopsis RecQI4A suppresses homologous recombination and modulates DNA damage responses.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100968.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-5' DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to abscisic acid stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    DNA helicase (RECQl4A)
    NP_172562.2
    • RECQ4A; FUNCTIONS IN: helicase activity, ATP-dependent 3'-5' DNA helicase activity, ATP-dependent helicase activity, nucleic acid binding, ATP binding; INVOLVED IN: chromosome organization, response to DNA damage stimulus, double-strand break repair via homologous recombination; LOCATED IN: intracellular; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RQC domain (InterPro:IPR018982), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (InterPro:IPR002464), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Helicase/RNase D C-terminal, HRDC domain (InterPro:IPR002121); BEST Arabidopsis thaliana protein match is: RECQ helicase L4B (TAIR:AT1G60930.1); Has 34923 Blast hits to 34782 proteins in 2821 species: Archae - 633; Bacteria - 21324; Metazoa - 3687; Fungi - 2728; Plants - 1606; Viruses - 18; Other Eukaryotes - 4927 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3647876..3655685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100968.3 → NP_172562.2  DNA helicase (RECQl4A) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172562.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04092, Q8L840, Q9FT71
      UniProtKB/TrEMBL
      A0A178W3L7
      Conserved Domains (7) summary
      smart00956
      Location:868 → 966
      RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
      PLN03137
      Location:1 → 1188
      PLN03137; ATP-dependent DNA helicase; Q4-like; Provisional
      cd00079
      Location:650 → 776
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      TIGR04420
      Location:955 → 1023
      Sec_Non_Glob; Sec region non-globular protein
      pfam00270
      Location:455 → 625
      DEAD; DEAD/DEAH box helicase
      pfam00570
      Location:1025 → 1090
      HRDC; HRDC domain
      pfam16124
      Location:781 → 858
      RecQ_Zn_bind; RecQ zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L840.1

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