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    Endoribonuclease/protein kinase IRE1-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820360, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Endoribonuclease/protein kinase IRE1-like protein
    Primary source
    TAIR:AT3G11870
    Locus tag
    AT3G11870
    See related
    Araport:AT3G11870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (3746998..3749093, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myosin-binding protein (Protein of unknown function, DUF593) Neighboring gene sterile alpha motif (SAM) domain protein Neighboring gene transmembrane protein, putative (Protein of unknown function DUF2359, transmembrane) Neighboring gene Sterile alpha motif (SAM) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtIRE1C, an unconventional isoform of the UPR master regulator AtIRE1, is functionally associated with AtIRE1B in Arabidopsis gametogenesis. Pu Y, et al. Plant Direct, 2019 Nov. PMID 31799493, Free PMC Article
    2. Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis. Mishiba KI, et al. Life Sci Alliance, 2019 Oct. PMID 31601623, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Endoribonuclease/protein kinase IRE1-like protein
    NP_187793.1
    • Endoribonuclease/protein kinase IRE1-like; FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1); Has 43296 Blast hits to 42939 proteins in 2046 species: Archae - 74; Bacteria - 4886; Metazoa - 17147; Fungi - 4251; Plants - 8096; Viruses - 78; Other Eukaryotes - 8764 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3746998..3749093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112020.1 → NP_187793.1  Endoribonuclease/protein kinase IRE1-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187793.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SF12
      UniProtKB/TrEMBL
      A0A178VGQ5, A0A5S9XBB5
      Conserved Domains (3) summary
      pfam00069
      Location:126 → 408
      Pkinase; Protein kinase domain
      cl15368
      Location:412 → 553
      RNase_Ire1_like; RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L
      cl21453
      Location:119 → 409
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SF12.1

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