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    MEK1 MAP kinase/ ERK kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828713, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEK1
    Official Full Name
    MAP kinase/ ERK kinase 1
    Primary source
    TAIR:AT4G26070
    Locus tag
    AT4G26070
    See related
    Araport:AT4G26070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMEK1; F20B18.180; F20B18_180; MAP kinase/ ERK kinase 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MKK1; NMAPKK
    Summary
    Member of MAP Kinase Kinase. Likely functions in a stress-activated MAPK pathway. Can phosphorylate the MAPK AtMPK4, in response to stress. Gets phosphorylated by MEKK1 in response to wounding.
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    Genomic context

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    See MEK1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (13217475..13219936)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L18ae family Neighboring gene Protein phosphatase 2C family protein Neighboring gene ncRNA Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene casein kinase 1 Neighboring gene nucleosome assembly protein1;1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterisation of MEK1, an Arabidopsis gene encoding a homologue of MAP kinase kinase. Morris PC, et al. Plant Mol Biol, 1997 Dec. PMID 9426629
    2. Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6. Desikan R, et al. Plant Physiol, 2001 Aug. PMID 11500556, Free PMC Article
    3. Knockout of AtMKK1 enhances salt tolerance and modifies metabolic activities in Arabidopsis. Conroy C, et al. Plant Signal Behav, 2013 May. PMID 23511202, Free PMC Article
    4. AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis. Xing Y, et al. J Exp Bot, 2007. PMID 17728292
    5. The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses. Chang CH, et al. Plant Mol Biol, 2023 Jan. PMID 36109466

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses.
      Title: The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses.
    2. Genetic and biochemical evidences not only show that MEK1-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
      Title: Role and interrelationship of MEK1-MPK6 cascade, hydrogen peroxide and nitric oxide in darkness-induced stomatal closure.
    3. AtMKK1 mutant plants tolerated elevated levels of salt during both germination and adulthood.
      Title: Knockout of AtMKK1 enhances salt tolerance and modifies metabolic activities in Arabidopsis.
    4. Data indicate that MEKK2 is required for the mekk1, mkk1 mkk2, and mpk4 autoimmune phenotypes.
      Title: Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted.
    5. Data suggest that the MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates MEKK2 and activation of MEKK2 triggers SUMM2-mediated immune responses.
      Title: The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis.
    6. miR-1826 plays an important role as tumor suppressor via CTNNB1/MEK1/VEGFC downregulation in bladder cancer.
      Title: MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer.
    7. ETS1 is probably mediating high CIP2A expression in human cancers with increased EGFR-MEK1/2-ERK pathway activity
      Title: ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.
    8. SDF-1alpha acts through CXCR4 to activate MEK and ERK, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of human osteosarcoma cells.
      Title: Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways.
    9. Activation of MPK4 by flg22 is impaired in the mkk1 mkk2 double mutants, suggesting that MKK1 and MKK2 function together with MPK4 and MEKK1 in a MAP kinase cascade to negatively regulate innate immune responses in plants.
      Title: MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants.
    10. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 and mpk4 mutants
      Title: Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341774.1
    NM_001341775.1
    NM_118740.3
    NM_179115.2
    NM_202890.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen-pistil interaction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase/ ERK kinase 1
    NP_194337.1
    • MAP kinase/ ERK kinase 1 (MEK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 2 (TAIR:AT4G29810.1); Has 130463 Blast hits to 128654 proteins in 4456 species: Archae - 177; Bacteria - 14997; Metazoa - 47934; Fungi - 12724; Plants - 32939; Viruses - 535; Other Eukaryotes - 21157 (source: NCBI BLink).
    NP_849446.1
    • MAP kinase/ ERK kinase 1 (MEK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 2 (TAIR:AT4G29810.1); Has 128112 Blast hits to 126672 proteins in 4377 species: Archae - 175; Bacteria - 14621; Metazoa - 47197; Fungi - 12494; Plants - 32367; Viruses - 521; Other Eukaryotes - 20737 (source: NCBI BLink).
    NP_974619.1
    • MAP kinase/ ERK kinase 1 (MEK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 2 (TAIR:AT4G29810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13217475..13219936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118740.3 → NP_194337.1  MAP kinase/ ERK kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04440, O04661, Q94A06
      UniProtKB/TrEMBL
      A0A178V3F2, A0A5S9XVY5, A0A7G2F2I6
      Conserved Domains (1) summary
      cd06623
      Location:66 → 332
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins

    2. NM_202890.2 → NP_974619.1  MAP kinase/ ERK kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04440, O04661, Q94A06
      UniProtKB/TrEMBL
      A0A178V3F2, A0A5S9XVY5, A0A7G2F2I6
      Conserved Domains (1) summary
      cd06623
      Location:66 → 332
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins

    3. NM_179115.2 → NP_849446.1  MAP kinase/ ERK kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2I6
      Conserved Domains (1) summary
      cd06623
      Location:66 → 306
      PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins

    4. NM_001341774.1 → NP_001328190.1  MAP kinase/ ERK kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3X1, A0A7G2F2I6

    5. NM_001341775.1 → NP_001328189.1  MAP kinase/ ERK kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3Y6, A0A7G2F2I6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94A06.2

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