ASE2 GLN phosphoribosyl pyrophosphate amidotransferase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ASE2
Official Full Name: GLN phosphoribosyl pyrophosphate amidotransferase 2
Primary source: TAIR:AT4G34740
Locus tag: AT4G34740
See related: Araport:AT4G34740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATASE2; ATPURF2; CHLOROPLAST IMPORT APPARATUS 1; CIA1; DIFFERENTIAL DEVELOPMENT OF VASCULAR ASSOCIATED CELLS; DOV1; F11I11.4; GLN phosphoribosyl pyrophosphate amidotransferase 2
Summary: Encodes glutamine 5-phosphoribosylpyrophosphate amidotransferase. Mutants are deficient in leaf, but not cotyledon, plastid and palisade cell development. Mutants exhibit defective chloroplast development under non-low light, suggesting that the defect in chloroplast development is caused by photo-oxidative damage. Plays role in differential development of vascular-associated cells. Demonstrates a cell-specific difference in chloroplast development.Mutant leaves are highly reticulate with a green vascular pattern.
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Genomic context

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See ASE2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (16574544..16576753, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATase2 plays an essential role in early chloroplast development through maintaining PEP function.
Title: Purine biosynthetic enzyme ATase2 is involved in the regulation of early chloroplast development and chloroplast gene expression in Arabidopsis.
mutant dov1 is impaired in the first step of purine metabolism
Title: The leaf reticulate mutant dov1 is impaired in the first step of purine metabolism.
DAS734 is a potent, slow-binding inhibitor.
Title: Chemical genetic identification of glutamine phosphoribosylpyrophosphate amidotransferase as the target for a novel bleaching herbicide in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119640.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables amidophosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables amidophosphoribosyltransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within purine nucleotide biosynthetic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in plastid stroma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GLN phosphoribosyl pyrophosphate amidotransferase 2

NP_195200.1

GLN phosphoribosyl pyrophosphate amidotransferase 2 (ASE2); FUNCTIONS IN: amidophosphoribosyltransferase activity; INVOLVED IN: purine base biosynthetic process, purine nucleotide biosynthetic process, leaf morphogenesis; LOCATED IN: plastid stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase, class-II (InterPro:IPR000583), Phosphoribosyltransferase (InterPro:IPR000836), Amidophosphoribosyl transferase (InterPro:IPR005854), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: GLN phosphoribosyl pyrophosphate amidotransferase 1 (TAIR:AT2G16570.1); Has 21535 Blast hits to 21523 proteins in 2920 species: Archae - 630; Bacteria - 12403; Metazoa - 419; Fungi - 318; Plants - 251; Viruses - 17; Other Eukaryotes - 7497 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16574544..16576753 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119640.3 → NP_195200.1 GLN phosphoribosyl pyrophosphate amidotransferase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195200.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39000, Q5MAT8, Q9STG9

UniProtKB/TrEMBL

A0A178UYQ3, A0A5S9XYN3

Conserved Domains (1) summary

PLN02440
Location:86 → 561

PLN02440; amidophosphoribosyltransferase