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    CSR1 chlorsulfuron/imidazolinone resistant 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824015, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSR1
    Official Full Name
    chlorsulfuron/imidazolinone resistant 1
    Primary source
    TAIR:AT3G48560
    Locus tag
    AT3G48560
    See related
    Araport:AT3G48560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACETOHYDROXY ACID SYNTHASE; ACETOLACTATE SYNTHASE; AHAS; ALS; chlorsulfuron/imidazolinone resistant 1; IMIDAZOLE RESISTANT 1; IMR1; TRIAZOLOPYRIMIDINE RESISTANT 5; TZP5
    Summary
    Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.
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    Genomic context

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    See CSR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (18001283..18003749, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cytidine/deoxycytidylate deaminase family protein Neighboring gene SHOOT GRAVITROPISM-like protein Neighboring gene secE/sec61-gamma protein transport protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Garcia MD, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28137884, Free PMC Article
    2. Dominance variation across six herbicides of the Arabidopsis thaliana csr1-1 and csr1-2 resistance alleles. Roux F, et al. Pest Manag Sci, 2005 Nov. PMID 16007690
    3. Intragenic recombination in the CSR1 locus of Arabidopsis. Mourad G, et al. Mol Gen Genet, 1994 Apr. PMID 8177214
    4. Acetolactate synthase regulatory subunits play divergent and overlapping roles in branched-chain amino acid synthesis and Arabidopsis development. Dezfulian MH, et al. BMC Plant Biol, 2017 Apr 7. PMID 28388946, Free PMC Article
    5. A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network. Xing A, et al. Plant Cell, 2017 Jun. PMID 28522547, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114714.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetolactate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyruvate decarboxylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-valine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    chlorsulfuron/imidazolinone resistant 1
    NP_190425.1
    • chlorsulfuron/imidazolinone resistant 1 (CSR1); FUNCTIONS IN: acetolactate synthase activity, pyruvate decarboxylase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TPP-binding enzyme, conserved site (InterPro:IPR000399), Thiamine pyrophosphate enzyme, central domain (InterPro:IPR012000), Acetolactate synthase, large subunit, biosynthetic (InterPro:IPR012846), Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (InterPro:IPR012001), Thiamine pyrophosphate enzyme, C-terminal TPP-binding (InterPro:IPR011766); BEST Arabidopsis thaliana protein match is: Thiamine pyrophosphate dependent pyruvate decarboxylase family protein (TAIR:AT5G17380.1); Has 30963 Blast hits to 30605 proteins in 2694 species: Archae - 488; Bacteria - 17421; Metazoa - 266; Fungi - 871; Plants - 599; Viruses - 25; Other Eukaryotes - 11293 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18001283..18003749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114714.3 → NP_190425.1  chlorsulfuron/imidazolinone resistant 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A174, P17597, Q5FV34, Q8L7Y7, Q94B64
      UniProtKB/TrEMBL
      A0A178VL64
      Conserved Domains (1) summary
      PLN02470
      Location:85 → 670
      PLN02470; acetolactate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17597.1

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