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    MRE11 DNA repair and meiosis protein (Mre11) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835514, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MRE11
    Official Full Name
    DNA repair and meiosis protein (Mre11)
    Primary source
    TAIR:AT5G54260
    Locus tag
    AT5G54260
    See related
    Araport:AT5G54260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MEIOTIC RECOMBINATION 11; ATMRE11; MDK4.8; MDK4_8; MEIOTIC RECOMBINATION 11
    Summary
    DNA repair and meiotic recombination protein, component of MRE11 complex with RAD50 and NBS1
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    Genomic context

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    See MRE11 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Sequence:
    Chromosome: 5; NC_003076.8 (22032038..22038052)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene membrane lipoprotein lipid attachment site-like protein, putative (DUF1223) Neighboring gene cyclic nucleotide-gated cation channel 4 Neighboring gene light-harvesting chlorophyll B-binding protein 3 Neighboring gene myosin 2 Neighboring gene cytochrome c biogenesis protein family Neighboring gene cotton fiber-like protein (DUF761)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thalianaMRE11 is essential for activation of cell cycle arrest, transcriptional regulation and DNA repair upon the induction of double-stranded DNA breaks. Šamanić I, et al. Plant Biol (Stuttg), 2016 Jul. PMID 27007017
    2. Evidence for distinct functions of MRE11 in Arabidopsis meiosis. Samanić I, et al. PLoS One, 2013. PMID 24205310, Free PMC Article
    3. The Arabidopsis thaliana DSB formation (AtDFO) gene is required for meiotic double-strand break formation. Zhang C, et al. Plant J, 2012 Oct. PMID 22694475
    4. Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato. Lohmiller LD, et al. Chromosoma, 2008 Jun. PMID 18293007
    5. The plant Rad50-Mre11 protein complex. Daoudal-Cotterell S, et al. FEBS Lett, 2002 Apr 10. PMID 11959125

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional and full-length AtMRE11 is essential for activation of the cell cycle arrest, transcriptional regulation and DNA repair upon induction of double strand break (DSB).
      Title: Arabidopsis thalianaMRE11 is essential for activation of cell cycle arrest, transcriptional regulation and DNA repair upon the induction of double-stranded DNA breaks.
    2. TAF1 interaction with MRE11 is mediated by the C-terminal bromodomain of TAF1.
      Title: Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte.
    3. functions of MRE11 in Arabidopsis meiosis
      Title: Evidence for distinct functions of MRE11 in Arabidopsis meiosis.
    4. The Atdfo Atmre11 double mutant had no such chromosome fragmentation, indicating that AtDFO is required for DNA double-strand break (DSB) formation.
      Title: The Arabidopsis thaliana DSB formation (AtDFO) gene is required for meiotic double-strand break formation.
    5. The cytological behavior of a possible early recombination nodules component, MRE11, a protein that is important for the repair of the numerous, programmed deoxyribonucleic acid double-strand breaks (DSBs) that occur early in the meiotic prophase.[
      Title: Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair and meiosis protein (Mre11)
    NP_200237.1
    • MEIOTIC RECOMBINATION 11 (MRE11); FUNCTIONS IN: hydrolase activity, manganese ion binding, protein serine/threonine phosphatase activity, exonuclease activity, endonuclease activity; INVOLVED IN: double-strand break repair, DNA metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), DNA repair exonuclease (InterPro:IPR003701), Mre11, DNA-binding (InterPro:IPR007281); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22032038..22038052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124806.2 → NP_200237.1  DNA repair and meiosis protein (Mre11) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XGM2
      UniProtKB/TrEMBL
      A0A178UN36, A0A7G2FK02
      Conserved Domains (3) summary
      TIGR00583
      Location:8 → 402
      mre11; DNA repair protein (mre11)
      cd00840
      Location:11 → 279
      MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
      pfam04152
      Location:302 → 452
      Mre11_DNA_bind; Mre11 DNA-binding presumed domain

    2. NM_001345081.1 → NP_001330550.1  DNA repair and meiosis protein (Mre11) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UN36, A0A1P8BB63, A0A7G2FK02
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XGM2.1

    Gene LinkOut

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