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    DNMT2 DNA methyltransferase-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832623, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DNMT2
    Official Full Name
    DNA methyltransferase-2
    Primary source
    TAIR:AT5G25480
    Locus tag
    AT5G25480
    See related
    Araport:AT5G25480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtDNMT2; DNA METHYLTRANSFERASE 2; DNA methyltransferase-2; T14C9.10; T14C9_10
    Summary
    Encodes a DNA methyltransferase homolog. Human Dnmt2 methylates tRNA-Asp and can methylate Arabidopsis tRNA-Asp in vitro.
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    Genomic context

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    See DNMT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (8869865..8872262, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein, putative (Protein of unknown function, DUF642) Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene Ran BP2/NZF zinc finger-like superfamily protein Neighboring gene exosome complex exonuclease Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance. Wadhwa N, et al. FEBS J, 2024 Jan. PMID 37584564
    2. Arabidopsis DNA methyltransferase AtDNMT2 associates with histone deacetylase AtHD2s activity. Song Y, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20331964
    3. bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis. Frerigmann H, et al. Plant Physiol, 2014 Sep. PMID 25049362, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance.
      Title: Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance.
    2. AtDNMT2 interacts with type-2 histone deacetylases (AtHD2s), a unique type of histone deacetylase family in plants.
      Title: Arabidopsis DNA methyltransferase AtDNMT2 associates with histone deacetylase AtHD2s activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122459.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA methyltransferase-2
    NP_568474.1
    • DNA methyltransferase-2 (DNMT2); FUNCTIONS IN: DNA binding; INVOLVED IN: DNA methylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: DNA methylase, C-5 cytosine-specific (InterPro:IPR001525); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8869865..8872262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122459.3 → NP_568474.1  DNA methyltransferase-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JWT7, Q6QPM1, Q8LER4
      UniProtKB/TrEMBL
      A0A178UTD0
      Conserved Domains (1) summary
      cd00315
      Location:15 → 381
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JWT7.1

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