U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CEN2 centrin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829855, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CEN2
    Official Full Name
    centrin 2
    Primary source
    TAIR:AT4G37010
    Locus tag
    AT4G37010
    See related
    Araport:AT4G37010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.11; AP22_11; centrin 2
    Summary
    Encodes a member of the Centrin family. Mutants are hypersensitive to UV and prone to UV induced DNA damage. Based on sequence similarity and mutant phenotype CEN2 is thought to be involved in nucelotide excision repair/DNA repair.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CEN2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (17444129..17445615)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene CLK4-associating serine/arginine-rich protein Neighboring gene heat shock factor 4 Neighboring gene accelerated cell death 2 (ACD2) Neighboring gene initiation factor 4A-like protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Binding of calcium and target peptide to calmodulin-like protein CML19, the centrin 2 of Arabidopsis thaliana. La Verde V, et al. Int J Biol Macromol, 2018 Mar. PMID 29129631
    2. SAC3B is a target of CML19, the centrin 2 of Arabidopsis thaliana. Pedretti M, et al. Biochem J, 2020 Jan 17. PMID 31860002
    3. CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein (AtRAD4) and contributes to efficient synthesis-dependent repair of bulky DNA lesions. Liang L, et al. Plant Mol Biol, 2006 May. PMID 16786311
    4. CENTRIN2 modulates homologous recombination and nucleotide excision repair in Arabidopsis. Molinier J, et al. Plant Cell, 2004 Jun. PMID 15155891, Free PMC Article
    5. Arabidopsis TONNEAU1 proteins are essential for preprophase band formation and interact with centrin. Azimzadeh J, et al. Plant Cell, 2008 Aug. PMID 18757558, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors propose that CML19 can bind to SAC3B (a component of transcription export complex 2) through its C-lobe independent of a Ca2+ stimulus, support a functional role for these proteins in TREX-2 complex (transcription export complex 2) and mRNA export.
      Title: SAC3B is a target of CML19, the centrin 2 of Arabidopsis thaliana.
    2. Binding of calcium and target peptide to calmodulin-like protein CML19, the centrin 2 of Arabidopsis thaliana
      Title: Binding of calcium and target peptide to calmodulin-like protein CML19, the centrin 2 of Arabidopsis thaliana.
    3. RAD4 interacts with the distal EF-hand Ca(2+) binding domain of CEN2 and this interaction is required for efficient nucleotide excision repair. [CEN2]
      Title: CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein (AtRAD4) and contributes to efficient synthesis-dependent repair of bulky DNA lesions.
    4. Role in homologous recombination and nucleotide excision repair. [CENTRIN2]
      Title: CENTRIN2 modulates homologous recombination and nucleotide excision repair in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001036721.2
    NM_119864.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    centrin 2
    NP_001031798.1
    • centrin 2 (CEN2); FUNCTIONS IN: calcium ion binding; INVOLVED IN: DNA repair; LOCATED IN: cytoplasm; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: centrin2 (TAIR:AT3G50360.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_195418.1
    • centrin 2 (CEN2); FUNCTIONS IN: calcium ion binding; INVOLVED IN: DNA repair; LOCATED IN: cytoplasm; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: centrin2 (TAIR:AT3G50360.1); Has 28959 Blast hits to 19034 proteins in 1566 species: Archae - 1; Bacteria - 97; Metazoa - 12402; Fungi - 5615; Plants - 6440; Viruses - 0; Other Eukaryotes - 4404 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17444129..17445615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036721.2 → NP_001031798.1  centrin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XZB1, A0A7G2F6M3, B6EUB9
      Conserved Domains (1) summary
      PTZ00183
      Location:15 → 169
      PTZ00183; centrin; Provisional

    2. NM_119864.5 → NP_195418.1  centrin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23184, Q8LCE6
      UniProtKB/TrEMBL
      A0A178V0A4, A0A654FW87
      Conserved Domains (1) summary
      PTZ00183
      Location:11 → 165
      PTZ00183; centrin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23184.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools