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    TOC64-V translocon at the outer membrane of chloroplasts 64-V [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830801, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOC64-V
    Official Full Name
    translocon at the outer membrane of chloroplasts 64-V
    Primary source
    TAIR:AT5G09420
    Locus tag
    AT5G09420
    See related
    Araport:AT5G09420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA TRANSLOCON AT THE OUTER MEMBRANE OF CHLOROPLASTS 64-V; AtmtOM64; ATTOC64-V; MTOM64; OM64; outer membrane 64; T5E8.220; T5E8_220; translocon at the outer membrane of chloroplasts 64-V
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    See TOC64-V in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (2928173..2932021)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene K+ uptake permease 7 Neighboring gene ethylene induced calmodulin binding protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene EXORDIUM like 4 Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the outer membrane mitochondrial protein OM64 influences protein import into mitochondria. Nickel C, et al. Mitochondrion, 2019 Jan. PMID 29374544
    2. Structural and Functional Heat Stress Responses of Chloroplasts of Arabidopsis thaliana. Paul P, et al. Genes (Basel), 2020 Jun 12. PMID 32545654, Free PMC Article
    3. Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana. Panigrahi R, et al. J Mol Recognit, 2014 Jun. PMID 24700626
    4. Quantification of interaction strengths between chaperones and tetratricopeptide repeat domain-containing membrane proteins. Schweiger R, et al. J Biol Chem, 2013 Oct 18. PMID 24036116, Free PMC Article
    5. Functional definition of outer membrane proteins involved in preprotein import into mitochondria. Lister R, et al. Plant Cell, 2007 Nov. PMID 17981999, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and Functional Heat Stress Responses of Chloroplasts of Arabidopsis thaliana.
      Title: Structural and Functional Heat Stress Responses of Chloroplasts of Arabidopsis thaliana.
    2. In summary, these data provide significant insight into the fine-tuning mechanisms of mitochondrial protein import mediated by phosphorylation of the cytosolic exposed receptor protein OM64.
      Title: Phosphorylation of the outer membrane mitochondrial protein OM64 influences protein import into mitochondria.
    3. the TPR domain from AtOm64 does not discriminate between the C-termini of Hsp70 and Hsp90. [AtOm64]
      Title: Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120979.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    translocon at the outer membrane of chloroplasts 64-V
    NP_196504.2
    • translocon at the outer membrane of chloroplasts 64-V (TOC64-V); FUNCTIONS IN: amidase activity, binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor; INVOLVED IN: protein targeting to mitochondrion; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Amidase (InterPro:IPR000120), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: translocon at the outer membrane of chloroplasts 64-III (TAIR:AT3G17970.1); Has 28606 Blast hits to 25511 proteins in 2588 species: Archae - 476; Bacteria - 13320; Metazoa - 3833; Fungi - 2411; Plants - 1768; Viruses - 0; Other Eukaryotes - 6798 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2928173..2932021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120979.3 → NP_196504.2  translocon at the outer membrane of chloroplasts 64-V [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196504.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KCL7, Q9FY73
      UniProtKB/TrEMBL
      A0A178UC85, A0A5S9Y394, A0A7G2FCA3
      Conserved Domains (3) summary
      TIGR00990
      Location:491 → 601
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:488 → 516
      TPR; TPR repeat [structural motif]
      cl18951
      Location:43 → 465
      Amidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KCL7.1

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