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    Vmn2r89 vomeronasal 2, receptor 89 [ Mus musculus (house mouse) ]

    Gene ID: 22301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vmn2r89provided by MGI
    Official Full Name
    vomeronasal 2, receptor 89provided by MGI
    Primary source
    MGI:MGI:1316707
    See related
    Ensembl:ENSMUSG00000070448 Ensembl:ENSMUSG00000121837 AllianceGenome:MGI:1316707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V2r10; V2r11
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be active in plasma membrane. Is expressed in vomeronasal organ sensory epithelium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vmn2r89 in Genome Data Viewer
    Location:
    14 C1; 14 26.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51689419..51698750)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51451962..51461293)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7247 Neighboring gene STARR-positive B cell enhancer mm9_chr14:52034327-52034627 Neighboring gene vomeronasal 2, receptor 88 Neighboring gene vomeronasal 2, receptor, pseudogene 111 Neighboring gene STARR-seq mESC enhancer starr_36673 Neighboring gene STARR-seq mESC enhancer starr_36675 Neighboring gene STARR-seq mESC enhancer starr_36676 Neighboring gene predicted gene 5622 Neighboring gene predicted gene 17175 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation. Hörnberg M, et al. J Neurochem, 2009 Aug. PMID 19519663
    2. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Matsunami H, et al. Cell, 1997 Aug 22. PMID 9288756
    3. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2, receptor 89
    Names
    vomeronasal organ family 2, receptor, 10
    vomeronasal organ family 2, receptor, 11
    vomeronasal receptor Vmn2r89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378723.2 → NP_001365652.1  vomeronasal 2, receptor 89 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      Related
      ENSMUST00000239412.4
      Conserved Domains (3) summary
      cd15283
      Location:581 → 832
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:508 → 561
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. NM_001385186.1 → NP_001372115.1  vomeronasal 2, receptor 89 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122858
      UniProtKB/TrEMBL
      A0A3B2WCB0
      Conserved Domains (3) summary
      cd15283
      Location:582 → 833
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:508 → 562
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RNA

    1. NR_104384.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons and uses an alternate splice site in the 3'-terminal exon, compared to variant 2. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC122858, AF011421
      Related
      ENSMUST00000161670.4

    2. NR_182098.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122858
      Related
      ENSMUST00000159734.5

    3. NR_182099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122858
      Related
      ENSMUST00000159611.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51689419..51698750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158577.1 → XP_036014470.1  vomeronasal 2, receptor 89 isoform X2

      Conserved Domains (2) summary
      cd15283
      Location:541 → 792
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    2. XM_017315984.1 → XP_017171473.1  vomeronasal 2, receptor 89 isoform X1

      Conserved Domains (3) summary
      cd15283
      Location:583 → 834
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:510 → 563
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06365
      Location:46 → 500
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

    3. XM_036158578.1 → XP_036014471.1  vomeronasal 2, receptor 89 isoform X3

      Conserved Domains (2) summary
      cd15283
      Location:506 → 757
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      cl10011
      Location:46 → 481
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009486.4: Suppressed sequence

      Description
      NM_009486.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.

    2. NM_009487.2: Suppressed sequence

      Description
      NM_009487.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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