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    Mon1a MON1 homolog A, secretory traffciking associated [ Mus musculus (house mouse) ]

    Gene ID: 72825, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mon1aprovided by MGI
    Official Full Name
    MON1 homolog A, secretory traffciking associatedprovided by MGI
    Primary source
    MGI:MGI:1920075
    See related
    Ensembl:ENSMUSG00000032583 AllianceGenome:MGI:1920075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810468K17Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein secretion. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 31.1), small intestine adult (RPKM 27.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mon1a in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107765282..107780338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107888083..107903139)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 5 Neighboring gene STARR-seq mESC enhancer starr_25188 Neighboring gene RNA binding motif protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E6802 Neighboring gene predicted gene, 23856 Neighboring gene macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Mon1-Ccz1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vacuolar fusion protein MON1 homolog A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028369.3NP_082645.1  vacuolar fusion protein MON1 homolog A

      See identical proteins and their annotated locations for NP_082645.1

      Status: VALIDATED

      Source sequence(s)
      AK013387, AW045198, BY064239
      Consensus CDS
      CCDS23508.1
      UniProtKB/TrEMBL
      A0A0R4J0D5, A0A0R4J2D4
      Related
      ENSMUSP00000035202.3, ENSMUST00000035202.4
      Conserved Domains (1) summary
      pfam03164
      Location:155555
      Mon1; Trafficking protein Mon1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107765282..107780338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313611.2XP_017169100.1  vacuolar fusion protein MON1 homolog A isoform X1

      Conserved Domains (1) summary
      pfam03164
      Location:32345
      Mon1; Trafficking protein Mon1

    RNA

    1. XR_001779021.2 RNA Sequence