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    Ip6k2 inositol hexaphosphate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 76500, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ip6k2provided by MGI
    Official Full Name
    inositol hexaphosphate kinase 2provided by MGI
    Primary source
    MGI:MGI:1923750
    See related
    Ensembl:ENSMUSG00000032599 AllianceGenome:MGI:1923750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ihpk2; 1500005N04Rik
    Summary
    Enables inositol hexakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process. Acts upstream of or within positive regulation of peptidyl-serine phosphorylation and protein stabilization. Located in nucleus. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 56.3), whole brain E14.5 (RPKM 54.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ip6k2 in Genome Data Viewer
    Location:
    9 F2; 9 59.63 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108660928..108683532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108783764..108806333)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259 Neighboring gene STARR-seq mESC enhancer starr_25226 Neighboring gene STARR-positive B cell enhancer ABC_E2307 Neighboring gene predicted gene, 23034 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene predicted gene, 35025

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107719

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavonoid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavonoid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables inositol hexakisphosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol hexakisphosphate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to flavonoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to flavonoid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inositol phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inositol phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inositol hexakisphosphate kinase 2
    Names
    insP6 kinase 2
    p(i)-uptake stimulator
    piUS
    NP_001366529.1
    NP_001366530.1
    NP_001366531.1
    NP_001366532.1
    NP_083910.2
    XP_006511914.1
    XP_006511916.1
    XP_006511917.1
    XP_006511918.1
    XP_006511919.1
    XP_036011296.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379600.1NP_001366529.1  inositol hexakisphosphate kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      Conserved Domains (1) summary
      pfam03770
      Location:202417
      IPK; Inositol polyphosphate kinase
    2. NM_001379601.1NP_001366530.1  inositol hexakisphosphate kinase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Conserved Domains (1) summary
      pfam03770
      Location:225440
      IPK; Inositol polyphosphate kinase
    3. NM_001379602.1NP_001366531.1  inositol hexakisphosphate kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      Conserved Domains (1) summary
      pfam03770
      Location:202417
      IPK; Inositol polyphosphate kinase
    4. NM_001379603.1NP_001366532.1  inositol hexakisphosphate kinase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC168054, AC173341
      UniProtKB/TrEMBL
      A0A0A6YWM3
      Related
      ENSMUSP00000141605.2, ENSMUST00000193560.6
      Conserved Domains (1) summary
      pfam03770
      Location:179394
      IPK; Inositol polyphosphate kinase
    5. NM_029634.2NP_083910.2  inositol hexakisphosphate kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_083910.2

      Status: VALIDATED

      Source sequence(s)
      AC168054
      Consensus CDS
      CCDS23537.1
      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Related
      ENSMUSP00000082091.5, ENSMUST00000085018.6
      Conserved Domains (1) summary
      pfam03770
      Location:225440
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108660928..108683532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511853.3XP_006511916.1  inositol hexakisphosphate kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006511916.1

    2. XM_006511855.3XP_006511918.1  inositol hexakisphosphate kinase 2 isoform X3

    3. XM_006511856.4XP_006511919.1  inositol hexakisphosphate kinase 2 isoform X4

      See identical proteins and their annotated locations for XP_006511919.1

      UniProtKB/TrEMBL
      A0A0A6YXT7
      Related
      ENSMUSP00000142134.2, ENSMUST00000192307.6
    4. XM_036155403.1XP_036011296.1  inositol hexakisphosphate kinase 2 isoform X3

    5. XM_006511851.5XP_006511914.1  inositol hexakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006511914.1

      UniProtKB/Swiss-Prot
      E9QMT6, Q80V72
      Conserved Domains (1) summary
      pfam03770
      Location:225440
      IPK; Inositol polyphosphate kinase
    6. XM_006511854.5XP_006511917.1  inositol hexakisphosphate kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006511917.1