U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lamb2 laminin, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 16779, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lamb2provided by MGI
    Official Full Name
    laminin, beta 2provided by MGI
    Primary source
    MGI:MGI:99916
    See related
    Ensembl:ENSMUSG00000052911 AllianceGenome:MGI:99916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lams; npht; Lamb-2
    Summary
    Enables integrin binding activity. A structural constituent of synapse-associated extracellular matrix. Acts upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Located in basement membrane and synapse. Part of laminin-3 complex. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including Reichert's membrane; alimentary system; brain; decidua; and submandibular gland primordium. Used to study Pierson syndrome and nephrosis. Human ortholog(s) of this gene implicated in Pierson syndrome; nephrotic syndrome type 5; and primary open angle glaucoma. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 79.6), heart adult (RPKM 69.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lamb2 in Genome Data Viewer
    Location:
    9 F2; 9 59.4 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108357080..108367729)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108479847..108490530)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC048562 Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206 Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within astrocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within axon extension involved in regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within metanephric glomerular basement membrane development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metanephric podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of basement membrane organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within visual perception IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of laminin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein complex involved in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit beta-2
    Names
    Laminin S
    S-LAM beta
    S-laminin subunit beta
    laminin-11 subunit beta
    laminin-14 subunit beta
    laminin-15 subunit beta
    laminin-3 subunit beta
    laminin-4 subunit beta
    laminin-7 subunit beta
    laminin-9 subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411228.1NP_001398157.1  laminin subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010508
      UniProtKB/Swiss-Prot
      Q61292, Q62182, Q8R0Y0
    2. NM_001411229.1NP_001398158.1  laminin subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010508
      UniProtKB/Swiss-Prot
      Q61292, Q62182, Q8R0Y0
    3. NM_008483.4NP_032509.2  laminin subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_032509.2

      Status: VALIDATED

      Source sequence(s)
      CT010508
      Consensus CDS
      CCDS23528.1
      UniProtKB/Swiss-Prot
      Q61292, Q62182, Q8R0Y0
      Related
      ENSMUSP00000069087.5, ENSMUST00000065014.10
      Conserved Domains (4) summary
      COG1196
      Location:12571789
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00055
      Location:524565
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:784832
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:64284
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108357080..108367729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)