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    Ggcx gamma-glutamyl carboxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ggcxprovided by RGD
    Official Full Name
    gamma-glutamyl carboxylaseprovided by RGD
    Primary source
    RGD:68383
    See related
    EnsemblRapid:ENSRNOG00000012975 AllianceGenome:RGD:68383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables gamma-glutamyl carboxylase activity and vitamin binding activity. Involved in several processes, including lung growth; peptidyl-glutamic acid carboxylation; and response to dexamethasone. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Biomarker of urolithiasis. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 261.8), Lung (RPKM 213.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ggcx in Genome Data Viewer
    Location:
    4q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106027918..106043653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104469737..104485631)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100277345..100293097)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 5 Neighboring gene uncharacterized LOC134486592 Neighboring gene vesicle-associated membrane protein 8 Neighboring gene uncharacterized LOC134486591 Neighboring gene methionine adenosyltransferase 2A Neighboring gene ATP synthase subunit g, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-glutamyl carboxylase activity  
    enables gamma-glutamyl carboxylase activity PubMed 
    enables gamma-glutamyl carboxylase activity  
    enables gamma-glutamyl carboxylase activity  
    enables peptide binding PubMed 
    enables vitamin binding  
    enables vitamin binding PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system  
    located_in endoplasmic reticulum membrane  
    is_active_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    vitamin K-dependent gamma-carboxylase
    Names
    peptidyl-glutamate 4-carboxylase
    vitamin K gamma glutamyl carboxylase
    vitamin K-dependent gamma-glutamyl carboxylase
    NP_113944.1
    XP_017448398.1
    XP_063142819.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031756.1NP_113944.1  vitamin K-dependent gamma-carboxylase

      See identical proteins and their annotated locations for NP_113944.1

      Status: PROVISIONAL

      Source sequence(s)
      AF065387
      UniProtKB/Swiss-Prot
      O88496
      UniProtKB/TrEMBL
      A0A8I6AAB6, B5DEF3, F7FCW3
      Related
      ENSRNOP00000088854.1, ENSRNOT00000107225.2
      Conserved Domains (2) summary
      smart00752
      Location:56315
      HTTM; Horizontally Transferred TransMembrane Domain
      pfam05090
      Location:66502
      VKG_Carbox; Vitamin K-dependent gamma-carboxylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106027918..106043653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592909.3XP_017448398.1  vitamin K-dependent gamma-carboxylase isoform X1

    2. XM_063286749.1XP_063142819.1  vitamin K-dependent gamma-carboxylase isoform X2

      UniProtKB/TrEMBL
      A6IAC0, Q497C4
      Related
      ENSRNOP00000072920.1, ENSRNOT00000084281.3
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